Document Detail


Evaluation of Matrix Metalloproteinase-2 in Lung Cancer.
MedLine Citation:
PMID:  24415566     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: There is an obvious need to diagnose lung cancer using novel non-invasive and sensitive biomarkers. In this regard, the aim of the present study was to evaluate and compare sputum MMP-2 in relation to serum MMP-2 of lung cancer patients and other non-malignant lung diseases in order to establish a new diagnostic and prognostic biomarker with a valid non-invasive technique.
DESIGN AND METHODS: Group (1) included (32) newly diagnosed lung cancer patients and group (2) included (20) patients with benign pulmonary diseases. In addition, (38) healthy subjects served as control group. MMP-2 activity levels were evaluated in serum and sputum samples of the studied groups using ELISA and zymography techniques.
RESULTS: There was a highly significant increase in serum and sputum MMP-2 levels in malignant group in comparison with benign and control groups. In addition, there was a significant difference in the levels of serum and sputum MMP-2 as regards the different histopathological types of lung cancer and advanced stages of lung cancer. Gelatin zymography was used to confirm the enzymatic activity of MMP-2. A higher MMP-2 activity was detected in lung cancer group in comparison with benign and control groups.
CONCLUSION: Serum and to a larger extent sputum MMP-2 appear to be potential non-invasive markers for detecting lung cancer. This article is protected by copyright. All rights reserved.
Authors:
Randa Ali-Labib; Manal Louis Louka; Iman Hassan El-Sayed Galal; Marwa Tarek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-10
Journal Detail:
Title:  Proteomics. Clinical applications     Volume:  -     ISSN:  1862-8354     ISO Abbreviation:  Proteomics Clin Appl     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101298608     Medline TA:  Proteomics Clin Appl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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