Document Detail

Evaluation of MRI criteria (1.5 T) for the diagnosis of hippocampal sclerosis in healthy subjects.
MedLine Citation:
PMID:  20307956     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The presence of hippocampal sclerosis (HS) on MRI has a great impact on the clinical evaluation and counselling of patients with temporal lobe epilepsy (TLE) and is considered as a key criterion for the decision to recommend epilepsy surgery. However, neuropathological studies describe evidence of HS in up to 10% of non-epileptic individuals, questioning the impact of this MRI finding in patients with TLE. We evaluated the prevalence of HS on MRI in the general population. METHODS: 100 healthy subjects and 10 patients with TLE due to HS were investigated in a prospective study using a specific protocol for the detection of hippocampal pathology (coronal FLAIR, coronal T2 TSE and a T1 weighted 3D SPGR sequence). RESULTS: HS was detected in none of the healthy subjects (95% confidence interval=0-3.6%), but in all patients. Inter-rater agreement was perfect for presence of HS. Thirty-three subjects had an unilaterally enlarged temporal horn as an isolated secondary criterion for HS and inter-rater agreement was slight for this point. Incidental pathological findings were detected in two patients (2%): one had a low grade astrocytoma (1%), one an aneurysm of the posterior communicating artery (1%). CONCLUSIONS: HS was not diagnosed in healthy subjects, supporting its impact on the evaluation of patients with temporal lobe epilepsy. An unilateral enlarged temporal horn that occurred in one third of the healthy subjects should not be considered as a pathologic finding or even as a marker for HS.
K Menzler; J Iwinska-Zelder; K Shiratori; R K Jaeger; W H Oertel; H M Hamer; F Rosenow; S Knake
Related Documents :
9546496 - Topographic distribution of seizure onset and hippocampal atrophy: relationship between...
8413976 - Diagnosis of medial temporal lobe seizure onset: relative specificity and sensitivity o...
9106286 - Cranial mri findings in myotonic dystrophy.
8213276 - Epilepsy in chronic subdural haematoma.
9082286 - Anterior nongranulomatous uveitis after intravitreal hpmpc (cidofovir) for the treatmen...
4032506 - Prehospital advanced trauma life support for critical penetrating wounds to the thorax ...
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2010-03-21
Journal Detail:
Title:  Epilepsy research     Volume:  89     ISSN:  1872-6844     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  349-54     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Interdisciplinary Epilepsy Center, Department of Neurology, Philipps-University of Marburg, Rudolf-Bultmann-Str. 8, 35033 Marburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Epilepsy, Temporal Lobe / diagnosis*,  pathology
Functional Laterality
Hippocampus / pathology*
Magnetic Resonance Imaging / methods*
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Memory in intellectually matched groups of young participants with 22q11.2 deletion syndrome and tho...
Next Document:  Thalamic changes in temporal lobe epilepsy with and without hippocampal sclerosis: A diffusion tenso...