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Evaluation of Large-Scale Combination HIV Prevention Programs: Essential Issues.
MedLine Citation:
PMID:  21694607     Owner:  NLM     Status:  Publisher    
HIV prevention research has shifted to the evaluation of combination prevention programs whereby biomedical, behavioral, and structural interventions are implemented concurrently to maximize synergies among interventions. However, these kinds of combination prevention packages, particularly when implemented at scale, pose significant evaluation challenges, including how best to determine impact and how and whether to measure the effectiveness of component strategies. In addition, methodological challenges unique to HIV infection such as the absence of a reliable incidence assay, the lack of naive control groups, and no suitable surrogates further complicate rigorous evaluation. In this commentary, we discuss the key considerations for planning impact evaluations of combination HIV prevention programs in light of these challenges, including defining the evaluable package, determining which component programs require independent assessment of impact, choosing study designs with valid counterfactuals, selecting appropriate outcomes of interest, and the importance of mid-course program corrections.
Nancy S Padian; Sandra I McCoy; Shanthi Manian; David Wilson; Bernhard Schwartländer; Stefano Bertozzi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-18
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  -     ISSN:  1944-7884     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Office of the U.S. Global AIDS Coordinator, U.S. Department of State, Washington, D.C. USA; 2 Institute of Business & Economic Research, University of California, Berkeley, California, USA; 3 Department of Epidemiology, University of California, Berkeley, California, USA; 4 Bill and Melinda Gates Foundation, Seattle, Washington, USA; 5 World Bank, Washington, D.C. USA; 6 Joint United Nations Programme on HIV/AIDS (UNAIDS), Geneva, Switzerland.
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