Document Detail


Evaluation of IL-12 serum level in patients with recalcitrant multiple common warts, treated by intralesional tuberculin antigen.
MedLine Citation:
PMID:  23336207     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background: No universal consensus about optimal modality for treating the recalcitrant multiple common warts (RMCW). Objective: To evaluate the immunological mechanisms and clinical therapeutic effect of using of intralesional (PPD) in the treatment of (RMRMCW). Methods: The study included 40 patients with (RMCW). They were randomly assigned to two groups; first group (20 patients) received intralesional PPD antigen, and second group (20 patients) received intralesional saline as a control group. Both treatments were injected into single lesions or largest wart in case of multiple lesions at weekly intervals until complete clearance or for a maximum of six treatments. Blood serum was taken at pre-study and at week 6 to measure IL-12 level. Results: A significant difference was found between the therapeutic responses of recalcitrant multiple common warts to PPD antigen and saline control group (P< 0.001). In the PPD group, complete response was achieved in 75% after 5.8 ± 0.7 sessions's patients presenting with recalcitrant multiple common warts. There was statistically significant increase in IL-12 of PPD group versus saline group. No recurrence was observed in PPD group. Conclusion: Intralesional immunotherapy by PPD antigen is effective and safe treatment for (RMCW) in previously immunized patients.
Authors:
Fian Abd-Elazeim; Ghada Mohammed; Amal Fathy; Roshdy Mohamed
Related Documents :
23924457 - Surgical closure of apical multiple muscular septal defects via right ventriculotomy us...
20691347 - Editor's comment and q&a efficiency of self-ligating vs conventionally ligated brackets...
1763837 - Long-term soft tissue response to lefort i maxillary superior repositioning.
23042087 - Diaphragm pacing and noninvasive respiratory management of amyotrophic lateral sclerosi...
19702357 - Hybrid procedures in the treatment of thoracoabdominal aortic aneurysms: a systematic r...
7253947 - Intravenous anaesthetics for minor gynecological operations.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Department of Dermatology and Venereology, Ismailia, Egypt.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  [Relationship between elderly hip fracture and osteoporosis].
Next Document:  Sensitivity of the BASC-2 Adaptive Skills Composite in Detecting Adaptive Impairment in a Clinically...