Document Detail

Evaluation of IL-12 serum level in patients with recalcitrant multiple common warts, treated by intralesional tuberculin antigen.
MedLine Citation:
PMID:  23336207     Owner:  NLM     Status:  Publisher    
Abstract Background: No universal consensus about optimal modality for treating the recalcitrant multiple common warts (RMCW). Objective: To evaluate the immunological mechanisms and clinical therapeutic effect of using of intralesional (PPD) in the treatment of (RMRMCW). Methods: The study included 40 patients with (RMCW). They were randomly assigned to two groups; first group (20 patients) received intralesional PPD antigen, and second group (20 patients) received intralesional saline as a control group. Both treatments were injected into single lesions or largest wart in case of multiple lesions at weekly intervals until complete clearance or for a maximum of six treatments. Blood serum was taken at pre-study and at week 6 to measure IL-12 level. Results: A significant difference was found between the therapeutic responses of recalcitrant multiple common warts to PPD antigen and saline control group (P< 0.001). In the PPD group, complete response was achieved in 75% after 5.8 ± 0.7 sessions's patients presenting with recalcitrant multiple common warts. There was statistically significant increase in IL-12 of PPD group versus saline group. No recurrence was observed in PPD group. Conclusion: Intralesional immunotherapy by PPD antigen is effective and safe treatment for (RMCW) in previously immunized patients.
Fian Abd-Elazeim; Ghada Mohammed; Amal Fathy; Roshdy Mohamed
Related Documents :
19875317 - Bilateral sagittal split osteotomies and mandibular distraction osteogenesis: a randomi...
9566167 - A modified, lingually supported cantilevered herbst appliance.
9594057 - The effect of non-surgical management of tm disorders.
23367677 - Botulinum toxin type a and neurogenic urinary incontinence: sometimes beneficial, if us...
19940397 - Percutaneous vertebroplasty using hydroxyapatite blocks for the treatment of vertebral ...
23682227 - Relationship between bronchial anthracofibrosis and endobronchial tuberculosis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Department of Dermatology and Venereology, Ismailia, Egypt.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  [Relationship between elderly hip fracture and osteoporosis].
Next Document:  Sensitivity of the BASC-2 Adaptive Skills Composite in Detecting Adaptive Impairment in a Clinically...