Document Detail

Evaluation of IL-12 serum level in patients with recalcitrant multiple common warts, treated by intralesional tuberculin antigen.
MedLine Citation:
PMID:  23336207     Owner:  NLM     Status:  Publisher    
Abstract Background: No universal consensus about optimal modality for treating the recalcitrant multiple common warts (RMCW). Objective: To evaluate the immunological mechanisms and clinical therapeutic effect of using of intralesional (PPD) in the treatment of (RMRMCW). Methods: The study included 40 patients with (RMCW). They were randomly assigned to two groups; first group (20 patients) received intralesional PPD antigen, and second group (20 patients) received intralesional saline as a control group. Both treatments were injected into single lesions or largest wart in case of multiple lesions at weekly intervals until complete clearance or for a maximum of six treatments. Blood serum was taken at pre-study and at week 6 to measure IL-12 level. Results: A significant difference was found between the therapeutic responses of recalcitrant multiple common warts to PPD antigen and saline control group (P< 0.001). In the PPD group, complete response was achieved in 75% after 5.8 ± 0.7 sessions's patients presenting with recalcitrant multiple common warts. There was statistically significant increase in IL-12 of PPD group versus saline group. No recurrence was observed in PPD group. Conclusion: Intralesional immunotherapy by PPD antigen is effective and safe treatment for (RMCW) in previously immunized patients.
Fian Abd-Elazeim; Ghada Mohammed; Amal Fathy; Roshdy Mohamed
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Department of Dermatology and Venereology, Ismailia, Egypt.
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