| Evaluation of IL-12 serum level in patients with recalcitrant multiple common warts, treated by intralesional tuberculin antigen. | |
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MedLine Citation:
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PMID: 23336207 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Background: No universal consensus about optimal modality for treating the recalcitrant multiple common warts (RMCW). Objective: To evaluate the immunological mechanisms and clinical therapeutic effect of using of intralesional (PPD) in the treatment of (RMRMCW). Methods: The study included 40 patients with (RMCW). They were randomly assigned to two groups; first group (20 patients) received intralesional PPD antigen, and second group (20 patients) received intralesional saline as a control group. Both treatments were injected into single lesions or largest wart in case of multiple lesions at weekly intervals until complete clearance or for a maximum of six treatments. Blood serum was taken at pre-study and at week 6 to measure IL-12 level. Results: A significant difference was found between the therapeutic responses of recalcitrant multiple common warts to PPD antigen and saline control group (P< 0.001). In the PPD group, complete response was achieved in 75% after 5.8 ± 0.7 sessions's patients presenting with recalcitrant multiple common warts. There was statistically significant increase in IL-12 of PPD group versus saline group. No recurrence was observed in PPD group. Conclusion: Intralesional immunotherapy by PPD antigen is effective and safe treatment for (RMCW) in previously immunized patients. |
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Authors:
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Fian Abd-Elazeim; Ghada Mohammed; Amal Fathy; Roshdy Mohamed |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-22 |
Journal Detail:
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Title: The Journal of dermatological treatment Volume: - ISSN: 1471-1753 ISO Abbreviation: J Dermatolog Treat Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8918133 Medline TA: J Dermatolog Treat Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Department of Dermatology and Venereology, Ismailia, Egypt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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