Document Detail


Evaluation of hydration and nutritional gels as supportive care after total-body irradiation in mice (Mus musculus).
MedLine Citation:
PMID:  20587164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concern regarding the potential for radiation exposure from accidents or nuclear and radiologic terrorism is increasing. The purpose of this study was to determine whether the addition of minimal supportive care consisting of hydration or nutritional gels could be used to reduce mortality in mice exposed to (60)Co gamma-radiation. Male CD2F1 mice received 0, 8.50, or 9.25 Gy (60)Co at a dose rate of 0.6 Gy/min. These groups were further divided into 3 treatment groups that-in addition to pelleted food and water-received no supportive care, hydration gel, or nutritional gel. Overall survival, mean survival time, consumption of pelleted food and gel, and body weight were recorded for 30 d. Radiation caused dose-dependent decreases in overall survival, consumption of pelleted food and supplemental gel, and body weight. However, at each radiation dose (0, 8.50, 9.25 Gy), the type of supportive care did not modify overall survival, mean survival time, or changes in body weight. These results demonstrate that hydration and nutritional gels were not effective methods of supportive care after high-dose total body irradiation in mice.
Authors:
Krinon D Moccia; Cara H Olsen; Jennifer M Mitchell; Michael R Landauer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Association for Laboratory Animal Science : JAALAS     Volume:  49     ISSN:  1559-6109     ISO Abbreviation:  J. Am. Assoc. Lab. Anim. Sci.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2011-04-01     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101269489     Medline TA:  J Am Assoc Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  323-8     Citation Subset:  IM    
Affiliation:
Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. moccia@afrri.usuhs.mil
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Cobalt Radioisotopes
Fluid Therapy*
Gamma Rays
Male
Mice
Mice, Inbred Strains
Nutritional Support*
Radiation Injuries, Experimental / mortality,  therapy*
Whole-Body Irradiation
Chemical
Reg. No./Substance:
0/Cobalt Radioisotopes
Comments/Corrections

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