Document Detail


Evaluation of How Gene-Job Strain Interaction Affects Blood Pressure in the PAMELA Study.
MedLine Citation:
PMID:  21364195     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: To see whether there is interaction between single nucleotide polymorphisms (SNPs) belonging to candidate genes for hypertension and job strain and its components (job demand and job control) in an accurately phenotyped Italian cohort (Pressioni Arteriose Monitorate E Loro Associazioni). Methods: From the Pressioni Arteriose Monitorate E Loro Associazioni cohort, we sampled 924 employed men and women who had completed a modified version of the Karasek questionnaire and for whom deoxyribonucleic acid information was available. We selected 1,510 common tagging and putative functional SNPs in 92 candidate autosomal genes involved in sympathetic nervous system, oxidative stress, renin-angiotensin-aldosterone system, and sodium balance. The interaction of each candidate SNP with the perceived job stress scores on ambulatory systolic and diastolic blood pressures was evaluated by adding product terms to a multiple regression linear model, adjusted for sex, age, total cholesterol, and body mass index. Results: Among all the SNPs tested, the interaction of SNP rs11210278 located on the endothelin 2 gene and job control was statistically significant after controlling for multiple testing, using false discovery rate (unadjusted p = .00000661; p adjusted for false discovery rate = .0085), indicating an inverse association with systolic blood pressure for the homozygous wild-type allele (C/C) and a positive association for the variant genotypes (C/T and T/T). Conclusions: We show that the hypertensive response to job strain is present only in carriers of the rs11210278 wild-type genotype. The phenomenon is discussed in relationship to the controversial results of field studies on job strain and hypertension.
Authors:
Cristina Menni; Vincenzo Bagnardi; Sandosh Padmanabhan; Rita Facchetti; Roberto Sega; Marco M Ferrario; Paolo Brambilla; Wai K Lee; Anna F Dominiczak; Giuseppe Mancia; Giancarlo Cesana
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-1
Journal Detail:
Title:  Psychosomatic medicine     Volume:  -     ISSN:  1534-7796     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Statistics (C.M., V.B.), University of Milano-Bicocca, Milano, Milano, Italy; BHF Glasgow Cardiovascular Research Centre (C.M., S.P., W.K.L., A.F.D.), University of Glasgow, Glasgow, UK; Division of Epidemiology and Biostatistics (V.B.), European Institute of Oncology, Milano, Italy; Study Centre on Public Health (R.F., R.S., M.M.F., G.C.) and the Department of Experimental Medicine (P.B.), University of Milano-Bicocca, Monza, Italy; and the Department of Clinical Medicine and Prevention (G.M.), University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy. from the British Heart Foundation (S.P.).
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