Document Detail

Evaluation of HLA-G5 plasmatic levels during pregnancy and relationship with the 14-bp polymorphism.
MedLine Citation:
PMID:  20482523     Owner:  NLM     Status:  In-Process    
PROBLEM: Plasmatic HLA-G levels increase during pregnancy, but the contribution of each different isoform has not been elucidated yet.
METHOD OF STUDY: HLA-G5 was analyzed by ELISA in 19 controls, 79 women in the first 8 weeks of pregnancy and in nine women monthly until delivery. Genotyping for the 14-bp polymorphism was performed by PCR amplification of exon 8.
RESULTS: HLA-G5 was detected in plasma from 80% of pregnant women. The levels did not change during pregnancy, and there were no differences compared to control non-pregnant women. There was a high interindividual variation that was maintained throughout the pregnancy. The presence of +14-bp allele was associated with HLA-G5 positivity. Pregnant women who were heterozygotic to 14-bp polymorphism had significantly higher levels of HLA-G5 compared to -14 bp/-14-bp homozygotic.
CONCLUSION: Plasmatic HLA-G5 levels do not change during pregnancy and its concentration depends on 14-bp polymorphism.
Alvaro Gonzalez; Estibaliz Alegre; Maria I Torres; Angel Díaz-Lagares; Pedro Lorite; Teresa Palomeque; Ainhoa Arroyo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  64     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  367-74     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Department of Biochemistry, University Clinic of Navarra, Pamplona, Spain.
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