| Evaluation of HLA-G5 plasmatic levels during pregnancy and relationship with the 14-bp polymorphism. | |
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MedLine Citation:
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PMID: 20482523 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PROBLEM: Plasmatic HLA-G levels increase during pregnancy, but the contribution of each different isoform has not been elucidated yet. METHOD OF STUDY: HLA-G5 was analyzed by ELISA in 19 controls, 79 women in the first 8 weeks of pregnancy and in nine women monthly until delivery. Genotyping for the 14-bp polymorphism was performed by PCR amplification of exon 8. RESULTS: HLA-G5 was detected in plasma from 80% of pregnant women. The levels did not change during pregnancy, and there were no differences compared to control non-pregnant women. There was a high interindividual variation that was maintained throughout the pregnancy. The presence of +14-bp allele was associated with HLA-G5 positivity. Pregnant women who were heterozygotic to 14-bp polymorphism had significantly higher levels of HLA-G5 compared to -14 bp/-14-bp homozygotic. CONCLUSION: Plasmatic HLA-G5 levels do not change during pregnancy and its concentration depends on 14-bp polymorphism. |
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Authors:
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Alvaro Gonzalez; Estibaliz Alegre; Maria I Torres; Angel Díaz-Lagares; Pedro Lorite; Teresa Palomeque; Ainhoa Arroyo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 64 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 367-74 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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Department of Biochemistry, University Clinic of Navarra, Pamplona, Spain. agonzaleh@unav.es |
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