Document Detail

Evaluation of Geranium spp., Helleborus spp. and Hyssopus spp. polyphenolic extracts inhibitory activity against urease and α-chymotrypsin.
MedLine Citation:
PMID:  23317419     Owner:  NLM     Status:  Publisher    
Abstract This study was meant to determine the inhibitory activity of tannins and flavonoid compounds from Geranium robertianum, Helleborus purpurascens and Hyssopus officinale plant polyphenol rich extracts against urease and α-chymotrypsin. The G. robertianum, H. purpurascens and H. officinale extracts were purified and concentrated by microfiltration and ultrafiltration. Phenolic compounds including flavonoids and tannins have been linked to many pharmacological activities. Thus, the polyphenolic content of the extracts was assessed by UV-Vis spectroscopy and HPLC. The concentrated extracts enriched in polyphenolic compounds (flavonoids, tannins and phenolic acids) showed a significant inhibition against urease from jack bean (over 90%), whereas in case of the α-chymotrypsin, they proved to have an inhibition below 54%. The results of this support the use of G. robertianum, H. purpurascens and H. officinale polyphenolic extracts as potential sources of urease inhibitors. Among the three plant extracts tested, H. officinale polyphenolic extracts exhibited a high inhibitory activity (92.67%) against urease and low inhibition (19.6%) against α-chymotrypsin and could be considered as possible remedy in ulcer treatment.
Gabriela Paun; Simona Carmen Litescu; Elena Neagu; Andreia Tache; Gabriel Lucian Radu
Related Documents :
20943689 - Spatial niche partitioning in dinosaurs from the latest cretaceous (maastrichtian) of n...
20303139 - Detection of dechlorane plus in fish from urban-industrial rivers.
7812439 - Sds-degrading bacteria attach to riverine sediment in response to the surfactant or its...
18341119 - Effect of climate change on fluxes of nitrogen from the tovdal river basin, norway, to ...
16152969 - Contaminant accumulation and biomarker responses in caged fish exposed to effluents fro...
12437289 - Estimation of sources of total phosphorus in a river basin and assessment of alternativ...
25113209 - Spatial distributions of methoxylated and hydroxylated polybrominated diphenyl ethers i...
12152749 - The sedimentation capabilities of hexadecyltrimethylammonium-modified montmorillonites.
21933319 - Production of plant growth modulating volatiles is widespread among rhizosphere bacteri...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Journal of enzyme inhibition and medicinal chemistry     Volume:  -     ISSN:  1475-6374     ISO Abbreviation:  J Enzyme Inhib Med Chem     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150203     Medline TA:  J Enzyme Inhib Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
National Institute for Research Development of Biological Sciences, Centre of Bioanalysis , 296 Spl. Independentei, PO Box 17-16, Bucharest 6 , Romania and.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) in posterolateral lumbar spine fusion: comp...
Next Document:  Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K/A...