Document Detail

Evaluation of the genotoxicity of chitosan nanoparticles for use in food packaging films.
MedLine Citation:
PMID:  20722945     Owner:  NLM     Status:  MEDLINE    
The use of nanoparticles in food packaging has been proposed on the basis that it could improve protection of foods by, for example, reducing permeation of gases, minimizing odor loss, and increasing mechanical strength and thermal stability. Consequently, the impacts of such nanoparticles on organisms and on the environment need to be investigated to ensure their safe use. In an earlier study, Moura and others (2008a) described the effect of addition of chitosan (CS) and poly(methacrylic acid) (PMAA) nanoparticles on the mechanical properties, water vapor, and oxygen permeability of hydroxypropyl methylcellulose films used in food packaging. Here, the genotoxicity of different polymeric CS/PMAA nanoparticles (size 60, 82, and 111 nm) was evaluated at different concentration levels, using the Allium cepa chromosome damage test as well as cytogenetic tests employing human lymphocyte cultures. Test substrates were exposed to solutions containing nanoparticles at polymer mass concentrations of 1.8, 18, and 180 mg/L. Results showed no evidence of DNA damage caused by the nanoparticles (no significant numerical or structural changes were observed), however the 82 and 111 nm nanoparticles reduced mitotic index values at the highest concentration tested (180 mg/L), indicating that the nanoparticles were toxic to the cells used at this concentration. In the case of the 60 nm CS/PMAA nanoparticles, no significant changes in the mitotic index were observed at the concentration levels tested, indicating that these particles were not toxic. The techniques used show promising potential for application in tests of nanoparticle safety envisaging the future use of these materials in food packaging.
Renata De Lima; Leandro Feitosa; Anderson do Espírito Santo Pereira; Márcia Regina de Moura; Fauze Ahmad Aouada; Luiz Henrique Capparelli Mattoso; Leonardo Fernandes Fraceto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of food science     Volume:  75     ISSN:  1750-3841     ISO Abbreviation:  J. Food Sci.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-20     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  N89-96     Citation Subset:  IM    
Dept. of Biotechnology, Univ. of Sorocaba, Sorocaba, SP, Brazil.
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MeSH Terms
Cells, Cultured
Chitosan / toxicity*
Chromosome Aberrations / drug effects
Chromosomes, Plant / drug effects
Cytogenetic Analysis
Dose-Response Relationship, Drug
Food Packaging*
Lymphocytes / drug effects
Microscopy, Electron, Transmission
Mitosis / drug effects
Mitotic Index
Mutagenicity Tests
Mutagens / toxicity*
Nanoparticles / chemistry*,  toxicity*,  ultrastructure
Onions / drug effects,  genetics
Particle Size
Plant Roots / drug effects
Polymethacrylic Acids / toxicity*
Seedling / drug effects,  genetics
Reg. No./Substance:
0/Mutagens; 0/Polymethacrylic Acids; 25087-26-7/polymethacrylic acid; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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