Document Detail


Evaluation of Genotoxicity of Antrodia cinnamomea in the Ames Test and the In Vitro Chromosomal Aberration Test.
MedLine Citation:
PMID:  21576417     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Antrodia cinnamomea is an expensive and highly valued folk medicinal fungus that grows only inside the rotten trunk of Cinnamomum kanehirae, an evergreen broad-leaved tree. This fungus has recently been used commercially in the formulation of nutraceuticals and functional foods in Taiwan. It has been used for centuries as a detoxificant in cases of food poisoning, diarrhea, vomiting, hepatic disease and various kinds of cancers. The present study investigated the effects of Antrodia cinnamomea on mutagenicity using a bacterial reverse mutation assay employing the Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535. The effects of Antrodia cinnamomea on chromosome structure were tested in Chinese hamster ovary (CHO) cells. Antrodia cinnamomea was not mutagenic in all bacterial strains and it was not genotoxic in CHO cells.
Authors:
Ming-Fang Wu; Fu-Chuo Peng; Yung-Liang Chen; Ching-Sung Lee; Yi-Yuan Yang; Ming-Yang Yeh; Chi-Ming Liu; Jin-Biou Chang; Rick Sai-Chuen Wu; Chieh-Chih Yu; Hsu-Feng Lu; Jing-Gung Chung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  25     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-05-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  419-23     Citation Subset:  IM    
Affiliation:
China Medical University, No 91, Hsueh-Shih Road, Taichung City 404, Taiwan, R.O.C. Tel: +886 4220533662500, jgchung@mail.cmu.edu.tw.
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