Document Detail

Evaluation of GBV-C/HGV viral load among HIV-1 co-infected patients in São Paulo, Brazil.
MedLine Citation:
PMID:  22242901     Owner:  NLM     Status:  Publisher    
Recent studies suggest that GBV-C/HGV infection in HIV-positive individuals is associated with a slower progression to AIDS, leading to a lower HIV viral load and higher counts of CD4 + T cells, although many studies have failed to demonstrate these beneficial effects. We developed a Real-Time PCR (TaqMan RT qPCR) to quantify the viral load of GBV-C/HGV in 102 HIV-1 infected patients, which were also evaluated for the presence of anti-E2. The prevalence of GBV-C/HGV infection was 21% among infected patients and mean plasma viral load of 3.62 ± 0.64 log10 copies/mL. Despite the high prevalence, there was no statistical difference when we compared the mean viral load (pvalue≤0.46), the average count of CD4 + (pvalue≤0.29) and CD8 + (pvalue≤0.64) among patients infected by GBV-C/HGV and HIV and patients infected only by HIV. This fact can be explained by the number of patients included in the study. Nevertheless, comparing to other studies, we observed a discrete number of patients with undetectable HIV load and lower median viral load in the group presenting GBV-C/HGV RNA. Our study suggests that there may be an impact on HIV viral load in GBV-C/HGV co-infected patients; however, further studies are needed to elucidate the molecular and cellular mechanisms involved in this viral interaction, previously reported in other studies, aiming to contribute to the development of new targets for drugs against HIV.
Viviane Kelly Alves-Sousa; Shirley Komninakis; Giovana Lotici Baggio-Zappia; Aline J Barbosa; Nathália Mantovani; Paulo Abrão; Graziela A Lanzara; Celso Granato
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-13
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  -     ISSN:  1931-8405     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Federal University of São Paulo, Infectious Diseases Division, São Paulo, Brazil;
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