| Evaluation of the FocalPoint GS system performance in an Italian population-based screening of cervical abnormalities. | |
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MedLine Citation:
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PMID: 18077978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the FocalPoint Location-Guided Screening (FPGS) performance in computer-assisted primary screening of Papanicolaou-stained cervicovaginal smears. STUDY DESIGN: A total of 37,306 routine consecutive conventional Pap slides were prospectively processed on the FPGS. Each slid designated by the instrument as Review was reported according to results obtained using a GS Review Station. Subsequently, all slides under went conventional manual rapid screening and reported results were compared. RESULTS: Of the slides initially submitted to the FPGS, 34,004 (91.15%) were qualified for scanning. Within these slides, the system classified 7,399 (21.8%) as needing No Further Review and ranked to Review the remaining 26,605 (78.2%). Of the 418 cellular abnormalities found, 409 were classified for Review by FPGS and 9 minor grade lesions were classified in the "No Further Review" population. Overall, 352 (86%) of atypical squamous cell (ASC)+ were ranked in high-score quintiles, including 96 (94%) of the 102 high-grade squamous intraepithelial lesion (HSIL) or worse. Location-guided software identified cellular abnormalities, in the automatically selected fields of view, in 378 (92%) of the ranked abnormal slides, showing a sensitivity > 95% on SILs. CONCLUSION: Slide ranking and location-guided screening features are of value in detecting and triaging abnormal smears. |
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Authors:
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Basilio Passamonti; Simonetta Bulletti; Maria Camilli; Maria Rosaria D'Amico; Eugenio Di Dato; Daniela Gustinucci; Nadia Martinelli; Morena Malaspina; Nicoletta Spita |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta cytologica Volume: 51 ISSN: 0001-5547 ISO Abbreviation: Acta Cytol. Publication Date: 2007 Nov-Dec |
Date Detail:
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Created Date: 2007-12-14 Completed Date: 2008-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370307 Medline TA: Acta Cytol Country: United States |
Other Details:
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Languages: eng Pagination: 865-71 Citation Subset: IM |
Affiliation:
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Department of Clinical Pathology, Cytology Center, Perugia, Italy. bpassamonti@ausl2.umbria.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cervical Intraepithelial Neoplasia / diagnosis Diagnosis, Computer-Assisted* Female Humans Italy Mass Screening / methods* Middle Aged Prospective Studies Uterine Cervical Diseases / classification, diagnosis*, prevention & control* Uterine Cervical Neoplasms / diagnosis, prevention & control Vaginal Smears / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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