| Evaluation of fluoride-induced oxidative stress in rat brain: a multigeneration study. | |
| | |
MedLine Citation:
|
PMID: 20658207 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Multigenerational evaluation was made in rats on exposure to high fluoride (100 and 200 ppm) to assess neurotoxic potential of fluoride in discrete areas of the brain in terms of lipid peroxidation and the activity of antioxidant enzyme system. The rats were given fluoride through drinking water (100 and 200 ppm) and maintained subsequently for three generations. Fluoride treatment significantly increased the lipid peroxidation and decreased the activity of antioxidant enzymes viz, catalase, superoxide dismutase, glutathione peroxidase, glutathione S-transferase, and glutathione level in first-generation rats and these alterations were more pronounced in the subsequent second and third-generation rats in both the doses tested. Decreased feed and water consumption, litter size and organ (brain) somatic index, marginal drop in body growth rate and mortality were observed in all three generations. Decreased antioxidant enzyme activity and increased malondialdehyde levels found in the present study might be related to oxidative damage that occurs variably in discrete regions of the brain. Results of this study can be taken as an index of neurotoxicity in rats exposed to water fluoridation over several generations. |
| | |
Authors:
|
P Mahaboob Basha; Puja Rai; Shabana Begum |
Related Documents
:
|
6745847 - Hepatic glutathione homeostasis in the rat: efflux accounts for glutathione turnover. 1417877 - Superoxide dismutase and glutathione peroxidase activities in rat pineal gland. 11701387 - Melatonin reduces oxidative stress induced by ochratoxin a in rat liver and kidney. 18558347 - Potential inhibitory effects of d-allose, a rare sugar, on liver preneoplastic lesion d... 11489547 - Increase of the ornithine decarboxylase/polyamine system and transglutaminase upregulat... 7398517 - Effect of improved absorption on development of jejunoileal bypass-induced liver dysfun... |
Publication Detail:
|
Type: Journal Article Date: 2010-07-24 |
Journal Detail:
|
Title: Biological trace element research Volume: 142 ISSN: 1559-0720 ISO Abbreviation: Biol Trace Elem Res Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-08-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: United States |
Other Details:
|
Languages: eng Pagination: 623-37 Citation Subset: IM |
Affiliation:
|
Bangalore University, Bangalore, India, pmbashabub@rediffmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: "Dead in bed": a tragic complication of type 1 diabetes mellitus.
Next Document: Effects of in-feed inclusion of clinoptilolite on blood serum concentrations of aluminium and inorga...