| Evaluation of The Federal Bureau of Prisons protocol for selection of which hepatitis C-infected inmates are considered for treatment. | |
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MedLine Citation:
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PMID: 15844707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Federal Bureau of Prisons limits hepatitis C therapy to those inmates with certain biochemical abnormalities. To evaluate this protocol, an analysis was done on data collected on hepatitis C infected inmates in the Louisiana Department of Corrections. A quality assurance database of hepatitis C infected inmates evaluated in the Louisiana Department of Corrections was reviewed for liver biopsy and laboratory results. Patients were compared as to whether they would have been biopsied under the Federal Bureau of Prisons protocol and if there were histologic differences between those who would and those who would not have been biopsied. Of 490 inmates biopsied, 26% (129) had an alanine aminotransferase level between one and two times the upper limit of normal without other biochemical abnormalities. If treating stages 2-4, 48% of these would qualify for treatment (15% if treating stages 3-4). There was no statistical difference between this group and either the group with an alanine aminotransferase level between one and two times the upper limit of normal and with other laboratory abnormalities or the group with an alanine aminotransferase level greater than or equal to two times the upper limit of normal and without other abnormalities. In the Louisiana Department of Corrections, the Federal Bureau of Prisons protocol was neither sensitive nor specific enough at identifying those that should be considered for hepatitis C therapy. |
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Authors:
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Monica M Pradhan; Ronald Horswell; Glenn Jones; Jennifer L Ramsey; William Cassidy |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 50 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-22 Completed Date: 2005-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 714-8 Citation Subset: AIM; IM |
Affiliation:
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Louisiana State University Health Sciences Center, Department of Medicine, Baton Rouge, Louisiana 70805, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine Transaminase / blood Antiviral Agents / therapeutic use* Biopsy Hepatitis C / blood, drug therapy*, pathology Humans Louisiana Male Patient Selection* Prisons* Sensitivity and Specificity United States |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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