Document Detail

Evaluation of fecal elastase and serum cholecystokinin in dogs with a false positive fecal elastase test.
MedLine Citation:
PMID:  20337909     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An assay for the measurement of pancreatic elastase in dog feces has been introduced. HYPOTHESIS/OBJECTIVES: The goal of this study was to evaluate the rate of false-positive fecal-elastase test results in dogs with suspected exocrine pancreatic insufficiency (EPI) and to assess serum cholecystokinin (CCK) concentrations in dogs with a false positive fecal elastase test result. ANIMALS: Twenty-six fecal and serum samples from dogs suspected of EPI, for which samples had been submitted to a commercial laboratory (Vet Med Labor) for analysis. METHODS: Prospective study. Serum trypsin-like immunoreactivity (TLI) was measured in 26 dogs with a decreased fecal elastase concentration of <10 microg/g feces. Serum CCK concentrations were measured in 21 of these dogs. RESULTS: Of 26 dogs with a decreased fecal elastase concentration, 6 (23%) had serum TLI concentrations within or above the reference range. Serum CCK concentrations were significantly higher in dogs with a true positive fecal elastase test result (median: 1.1 pmol/L; range: 0.1-3.3 pmol/L) than in those with a false positive fecal elastase test result (median: 0.1 pmol/L; range: 0.1-0.9 pmol/L; P value = .0163). CONCLUSIONS AND CLINICAL IMPORTANCE: The rate of false positive fecal elastase test results was high in this group of dogs, suggesting that diagnosis of EPI must be confirmed by other means. The decreased CCK concentration in dogs with a false positive fecal elastase test result could suggest that false positive results are because of decreased stimulation of exocrine pancreatic function caused by other conditions.
J M Steiner; J F Rehfeld; N Pantchev
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Publication Detail:
Type:  Journal Article     Date:  2010-03-15
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  24     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  643-6     Citation Subset:  IM    
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
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MeSH Terms
Cholecystokinin / blood*
Dog Diseases / diagnosis*,  metabolism
Exocrine Pancreatic Insufficiency / blood,  diagnosis,  enzymology,  veterinary*
False Positive Reactions*
Feces / chemistry*
Pancreas / enzymology
Pancreatic Elastase / analysis*
Reg. No./Substance:
9011-97-6/Cholecystokinin; EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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