| Evaluation of the Effects of Thyrotropin Releasing Hormone (TRH) Therapy on Regional Cerebral Blood Flow in the Cerebellar Variant of Multiple System Atrophy Using 3DSRT. | |
| | |
MedLine Citation:
|
PMID: 19674246 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Thyrotropin releasing hormone (TRH) improves cerebellar ataxia and cerebellar perfusion in patients with spinocerebellar degeneration. It is not known whether TRH therapy can improve the cerebellar regional cerebral blood flow (rCBF) or not in patients with cerebellar variant of multiple-system atrophy (MSA-C). PATIENTS AND METHODS: Seven patients with MSA-C received TRH intravenously (2 mg/day) for 14 days. Clinical efficacy was assessed using the International Cooperative Ataxia Rating Scale (ICARS) and brain perfusion single photon emission-computed tomography was performed before and after therapy. The rCBF in each region of interest (ROI) was calculated using 3DSRT, a fully automated the ROI technique. RESULTS: The ICARS scores slightly improved in 6 of the 7 patients after TRH therapy, but this was not statistically significant. After TRH therapy, the cerebellar rCBF reduced in the 6 of 7 patients and the mean rCBF in cerebellum also significantly decreased (P= 0.029, paired t-test), whereas the rCBF in the precentral segment tend to increase (P= 0.048, paired t-test). CONCLUSION: TRH therapy may be less effective on cerebellar ataxia and cerebellar rCBF in MSA-C. The 3DSRT program may be useful for the evaluation of the efficacy of TRH therapy on cerebral blood flow. |
| | |
Authors:
|
Noriyuki Kimura; Toshihide Kumamoto; Teruaki Masuda; Yuki Nomura; Takuya Hanaoka; Yusuke Hazama; Toshio Okazaki |
Related Documents
:
|
2784226 - Neuroanatomical correlates of anticipatory anxiety. 15918546 - Evaluation of cingulate gyrus blood flow in patients with liver cirrhosis. 9126896 - Hemodynamic and metabolic disturbances in patients with intracranial dural arteriovenou... 2481186 - Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke. 18400276 - Portable ultrasonography and bladder volume accuracy--a comparative study using three-d... 9513896 - Cortical and medullary hemodynamics in deoxycorticosterone acetate-salt hypertensive mice. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 21 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
|
Languages: eng Pagination: 132-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2009 by the American Society of Neuroimaging. |
Affiliation:
|
From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Unusual presentation of sarcoidosis: solitary intracranial mass lesion mimicking a glioma.
Next Document: DWI lesion volume reduction following acute stroke treatment with transient partial aortic obstructi...