| Evaluation of Different Perfusion Durations in Direct Hemoperfusion with Polymyxin B-Immobilized Fiber Column Therapy for Acute Exacerbation of Interstitial Pneumonias. | |
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MedLine Citation:
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PMID: 21372564 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Recently, the potential therapeutic effect of direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) has been reported for acute exacerbation of interstitial pneumonia (AE-IP), a highly morbid clinical event; however, there is no consensus on the appropriate procedure for PMX-DHP. We examined the appropriate perfusion duration of PMX-DHP for AE-IP. Methods: AE-IP patients receiving PMX-DHP were divided into two groups: short-duration group (≤6 h) (n = 5) and long-duration group (12 h) (n = 12). Results: ThePaO(2)/FiO(2) (P/F) ratio increased immediately after PMX-DHP in the two groups. In the long-duration group, the P/F ratio continued to increase over the following 7 days, while, in the short-duration group, the P/F ratio declined again 3 days after therapy. The survival rate 30 days after PMX-DHP was significantly higher in the long-duration group than in the short-duration group. Conclusions: A long perfusion duration of PMX-DHP is more efficacious for AE-IP than a short perfusion duration. |
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Authors:
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Masato Kono; Takafumi Suda; Noriyuki Enomoto; Yutaro Nakamura; Yusuke Kaida; Dai Hashimoto; Naoki Inui; Tomoaki Mizuguchi; Akihiko Kato; Toshihiro Shirai; Hirotoshi Nakamura; Kingo Chida |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-02 |
Journal Detail:
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Title: Blood purification Volume: 32 ISSN: 1421-9735 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402040 Medline TA: Blood Purif Country: - |
Other Details:
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Languages: ENG Pagination: 75-81 Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Second Division, Department of Internal Medicine, Hamamatsu, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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