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Evaluation of Different Perfusion Durations in Direct Hemoperfusion with Polymyxin B-Immobilized Fiber Column Therapy for Acute Exacerbation of Interstitial Pneumonias.
MedLine Citation:
PMID:  21372564     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Recently, the potential therapeutic effect of direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) has been reported for acute exacerbation of interstitial pneumonia (AE-IP), a highly morbid clinical event; however, there is no consensus on the appropriate procedure for PMX-DHP. We examined the appropriate perfusion duration of PMX-DHP for AE-IP. Methods: AE-IP patients receiving PMX-DHP were divided into two groups: short-duration group (≤6 h) (n = 5) and long-duration group (12 h) (n = 12). Results: ThePaO(2)/FiO(2) (P/F) ratio increased immediately after PMX-DHP in the two groups. In the long-duration group, the P/F ratio continued to increase over the following 7 days, while, in the short-duration group, the P/F ratio declined again 3 days after therapy. The survival rate 30 days after PMX-DHP was significantly higher in the long-duration group than in the short-duration group. Conclusions: A long perfusion duration of PMX-DHP is more efficacious for AE-IP than a short perfusion duration.
Authors:
Masato Kono; Takafumi Suda; Noriyuki Enomoto; Yutaro Nakamura; Yusuke Kaida; Dai Hashimoto; Naoki Inui; Tomoaki Mizuguchi; Akihiko Kato; Toshihiro Shirai; Hirotoshi Nakamura; Kingo Chida
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-02
Journal Detail:
Title:  Blood purification     Volume:  32     ISSN:  1421-9735     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  -    
Other Details:
Languages:  ENG     Pagination:  75-81     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Second Division, Department of Internal Medicine, Hamamatsu, Japan.
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