| Evaluation of the correlation between colour power Doppler flow imaging and vascular endothelial growth factor in breast cancer. | |
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MedLine Citation:
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PMID: 20819445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to evaluate the correlation between blood flow, using colour power Doppler flow imaging [CPDI], and protein levels of vascular endothelial growth factor (VEGF), as measured by optical density (OD), in breast tumours. Breast cancer patients were observed pre-operatively using CPDI and VEGF protein levels were quantified by immunohistochemistry, and the correlation between the two was studied. The relationship between tumour angiogenesis and axillary lymph node (LN) metastasis was also analysed. Blood-flow grade was higher in the LN(+) group than in the LN(-) group; grade II - III blood flow was 88.9% in the LN(+) group. The VEGF protein levels in the LN(+) group were also higher than in the LN(-) group. A significant positive correlation was observed between blood-flow grade and OD value for VEGF protein. Breast tumour angiogenesis was closely correlated with axillary LN metastasis. Higher blood flow was related to elevated VEGF protein levels and an increased risk of axillary node metastasis. CPDI could, therefore, indirectly demonstrate tumour angiogenesis before surgery, enabling planning of treatment and assessment of the prognosis. |
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Authors:
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Y Wang; H-J Dan; J-H Fan; S-B Wen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of international medical research Volume: 38 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-09-07 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 1077-83 Citation Subset: IM |
Affiliation:
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Department of Ultrasound in Medicine, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China. msyanwang2008@163.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Breast Neoplasms / blood supply*, metabolism, pathology Carcinoma, Ductal, Breast / blood supply*, metabolism, secondary Carcinoma, Lobular / blood supply*, metabolism, secondary Female Fluorescent Antibody Technique, Direct Humans Lymph Nodes / pathology Lymphatic Metastasis Middle Aged Regional Blood Flow Reproducibility of Results Tumor Markers, Biological / metabolism Ultrasonography, Doppler, Color / methods* Vascular Endothelial Growth Factor A / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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