| Evaluation of the Correlation Between Genetic Damage and Occupational Chromate Exposure Through BNMN Frequencies. | |
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MedLine Citation:
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PMID: 22157804 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:: To evaluate the correlation between chromate exposure and binucleated cells with micronuclei (BNMN) frequencies in chromate production workers and explore the ideal biomarker to detect early DNA damage. METHODS:: There are 79 workers and 112 peasants in this study. Chromium concentrations in the air (CrA), blood (CrB), and urine (CrU) were detected. BNMN frequencies were also counted. RESULTS:: The CrA, CrB, CrU, and BNMN frequencies of the exposure group were higher than those of the control group; BNMN frequencies were positively correlated with CrB and CrU; natural logarithm (Ln) BNMN was regressed on CrB, CrU, and CrA by linear models. CONCLUSIONS:: The increases in CrB, CrU, and BNMN frequencies caused by lower CrA level suggest BNMN frequencies could be used to detect early DNA damage in the chromate production health surveillance. |
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Authors:
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Liu Xiaohua; Song Yanshuang; Wang Li; Li Yuhui; Zhang Ji; Ma Yanhui; Wang Yun; Ma Wenjun; Yan Lei; Jia Guang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-9 |
Journal Detail:
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Title: Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine Volume: - ISSN: 1536-5948 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504688 Medline TA: J Occup Environ Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the School of Public Health (Drs Xiaohua, Yanshuang, and Guang and Mss Lei and Wenjun), Department of Occupational and Environmental Health Sciences, Peking University, Beijing, China; Baotou Medical College (Ms Li), Baotou City; Hospital of Inner Mongolia North Heavy Industries Group (Ms Li), the Inner Monggol Autonomous Region, China; and Jinan Municipal Center for Disease Control & Prevention (Ms Yanhui and Ji), Shandong Province, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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