Document Detail


Evaluation of ChloraPrep (2% chlorhexidine gluconate in 70% isopropyl alcohol) for skin antisepsis in preparation for blood culture collection.
MedLine Citation:
PMID:  18848729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Blood culture contamination is a significant adverse event. This study evaluated whether using ChloraPrep (2% alcoholic chlorhexidine) instead of 70% isopropyl alcohol wipes reduced contamination rates on two Medical Assessment Units (MAU1 and MAU2).
METHODS: ChloraPrep was introduced for 2 to 3-month intervention periods, initially on MAU1 and MAU2 and subsequently on MAU1 only. Contamination rates were compared with a matched time period in the preceding year and the three month period before ChloraPrep introduction. Education regarding venepucture technique was delivered.
RESULTS: Contamination rates for the time matched pre-intervention period were 17.3% (51/295), MAU1 and 13.5% (31/230), MAU2. During the initial period of ChloraPrep use, rates declined (MAU1; 6.6% [P<0.001], MAU2; 8.5% [P=0.11] both Fisher's Exact Test). However, rates had already started to fall prior to ChloraPrep introduction. There was a non-significant difference between contamination rates in the comparator period immediately prior to ChloraPrep introduction and rates during the first intervention period (MAU1 and MAU2; P>0.05). During the second intervention period, absence of ChloraPrep on MAU2 did not significantly affect contamination (P=0.41) on this ward.
CONCLUSIONS: ChloraPrep skin antisepsis did not give a significant reduction in blood culture contamination, but education may have led to the trend to lower contamination.
Authors:
E McLellan; R Townsend; H K Parsons
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-10-10
Journal Detail:
Title:  The Journal of infection     Volume:  57     ISSN:  1532-2742     ISO Abbreviation:  J. Infect.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-01-05     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7908424     Medline TA:  J Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-63     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Herries Road, Sheffield S5 7AU, United Kingdom. elizabeth.mclellan@sth.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
2-Propanol / pharmacology*
Antisepsis / methods*
Attitude of Health Personnel
Blood / microbiology*
Chlorhexidine / analogs & derivatives*,  pharmacology
Disinfectants / pharmacology*
Education
Hospitals
Humans
Skin / microbiology*
Chemical
Reg. No./Substance:
0/Disinfectants; 55-56-1/Chlorhexidine; 67-63-0/2-Propanol; MOR84MUD8E/chlorhexidine gluconate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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