| Evaluation of ChloraPrep (2% chlorhexidine gluconate in 70% isopropyl alcohol) for skin antisepsis in preparation for blood culture collection. | |
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MedLine Citation:
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PMID: 18848729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Blood culture contamination is a significant adverse event. This study evaluated whether using ChloraPrep (2% alcoholic chlorhexidine) instead of 70% isopropyl alcohol wipes reduced contamination rates on two Medical Assessment Units (MAU1 and MAU2). METHODS: ChloraPrep was introduced for 2 to 3-month intervention periods, initially on MAU1 and MAU2 and subsequently on MAU1 only. Contamination rates were compared with a matched time period in the preceding year and the three month period before ChloraPrep introduction. Education regarding venepucture technique was delivered. RESULTS: Contamination rates for the time matched pre-intervention period were 17.3% (51/295), MAU1 and 13.5% (31/230), MAU2. During the initial period of ChloraPrep use, rates declined (MAU1; 6.6% [P<0.001], MAU2; 8.5% [P=0.11] both Fisher's Exact Test). However, rates had already started to fall prior to ChloraPrep introduction. There was a non-significant difference between contamination rates in the comparator period immediately prior to ChloraPrep introduction and rates during the first intervention period (MAU1 and MAU2; P>0.05). During the second intervention period, absence of ChloraPrep on MAU2 did not significantly affect contamination (P=0.41) on this ward. CONCLUSIONS: ChloraPrep skin antisepsis did not give a significant reduction in blood culture contamination, but education may have led to the trend to lower contamination. |
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Authors:
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E McLellan; R Townsend; H K Parsons |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-10-10 |
Journal Detail:
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Title: The Journal of infection Volume: 57 ISSN: 1532-2742 ISO Abbreviation: J. Infect. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-05 Completed Date: 2009-01-05 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 7908424 Medline TA: J Infect Country: England |
Other Details:
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Languages: eng Pagination: 459-63 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Herries Road, Sheffield S5 7AU, United Kingdom. elizabeth.mclellan@sth.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Propanol
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pharmacology* Antisepsis / methods* Attitude of Health Personnel Blood / microbiology* Chlorhexidine / analogs & derivatives*, pharmacology Disinfectants / pharmacology* Education Hospitals Humans Skin / microbiology* |
| Chemical | |
Reg. No./Substance:
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0/Disinfectants; 55-56-1/Chlorhexidine; 67-63-0/2-Propanol; MOR84MUD8E/chlorhexidine gluconate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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