| PET/CT evaluation of cervical cancer: spectrum of disease. | |
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MedLine Citation:
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PMID: 20833849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prognosis of invasive cervical cancer is based on the stage, size, and histologic grade of the primary tumor and the status of the lymph nodes. Assessment of disease stage is essential in determining proper management in individual cases. In the posttherapy setting, the timely detection of recurrence is essential for guiding management and may lead to increased survival. However, the official clinical staging system of the International Federation of Gynecology and Obstetrics has inherent flaws that may lead to inaccurate staging and improper management. Combined positron emission tomography (PET)/computed tomography (CT) represents a major technologic advance, consisting of two integrated complementary modalities whose combined strength tends to overcome their respective weaknesses. PET/CT has higher sensitivity and specificity than do conventional anatomic modalities and is valuable in determining the extent of disease and detecting recurrent or residual tumor. The combination of 2-[fluorine-18]fluoro-2-deoxy-d-glucose PET with intravenous contrast material-enhanced high-resolution CT has proved useful for avoiding the interpretative weaknesses associated with either modality alone and in increasing the accuracy of staging or restaging. Nonetheless, accurate PET/CT interpretation requires a knowledge of the characteristics of disease spread or recurrence and an awareness of various imaging pitfalls if false interpretations are to be avoided. |
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Authors:
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Hongju Son; Arpakorn Kositwattanarerk; Monica P Hayes; Linus Chuang; Jamal Rahaman; Sherif Heiba; Josef Machac; Konstantin Zakashansky; Lale Kostakoglu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiographics : a review publication of the Radiological Society of North America, Inc Volume: 30 ISSN: 1527-1323 ISO Abbreviation: Radiographics Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8302501 Medline TA: Radiographics Country: United States |
Other Details:
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Languages: eng Pagination: 1251-68 Citation Subset: IM |
Affiliation:
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Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Fluorodeoxyglucose F18 / diagnostic use* Humans Image Enhancement / methods* Internationality Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Subtraction Technique Tomography, X-Ray Computed / methods* Uterine Cervical Neoplasms / classification*, diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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