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Evaluation of cadmium, chromium, nickel, and zinc in biological samples of psoriasis patients living in pakistani cement factory area.
MedLine Citation:
PMID:  20665125     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Psoriasis is a noncontiguous common and chronic skin disorder. The aim of the present study was to compare the level of trace elements cadmium (Cd), chromium (Cr), Nickel (Ni), and zinc (Zn) in biological samples (whole blood, urine, and scalp hair) of psoriasis patients of both gender age ranged (25-55 years) at mild, moderate severe, and more severe stage (n = 418) living in the vicinity of cement factory. For comparison purposes, healthy age-matched referent subjects, residents of industrial and non-industrial area, of both gender were also selected (n = 241). The concentrations of trace and toxic elements were measured by atomic absorption spectrophotometer prior to microwave-assisted acid digestion. The validity and accuracy of methodology was checked by using certified reference materials (CRMs) and conventional wet acid digestion method on same CRMs and real samples. The results of this study showed that the mean values of Cd, Cr, Ni, and Pb were significantly higher in scalp hair, blood, and urine samples of mild and severe psoriasis patients as compared to referents (p < 0.001), while the concentration of Zn was lower in the scalp hair and blood, but higher in the urine samples of psoriasis patients. The deficiency of Zn in psoriasis patients may be undoubtedly caused by the toxic element exposures via cement factory.
Authors:
Hassan Imran Afridi; Tasneem Gul Kazi; Naveed Kazi; Ghulam Abbas Kandhro; Jameel Ahmed Baig; Abdul Qadir Shah; Sumaira Khan; Nida Fatima Kolachi; Sham Kumar Wadhwa; Faheem Shah; Mohammad Khan Jamali; Mohammad Balal Arain
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Publication Detail:
Type:  Journal Article     Date:  2010-07-28
Journal Detail:
Title:  Biological trace element research     Volume:  142     ISSN:  1559-0720     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  284-301     Citation Subset:  IM    
Affiliation:
National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan, hassanimranafridi@yahoo.com.
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