Document Detail


[Evaluation of Bone ; Up Date from Research to Clinical Application. Analysis of bone tissues by using fluorescent imaging].
MedLine Citation:
PMID:  23445887     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Rapid development of fluorescent imaging techniques enables us to understand cellular dynamics in vivo . We have originally established an advanced imaging system for visualizing live bone tissues with intravital multiphoton microscopy. By means of the system we have recently succeeded in visualization of mature osteoclasts in live bones and revealed that RANKL regulates bone-resorptive functions of mature osteoclasts in vivo . We also developed new image analysis software for tracking morphological changes of mature osteoclasts and generated pH-sensing chemical fluorescent probes for detecting bone resorption at local sites on the bone surface. Here we show the latest data and the detailed methodology of intravital imaging of bone tissues, and also discuss its further application.
Authors:
Junichi Kikuta; Masaru Ishii
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Clinical calcium     Volume:  23     ISSN:  0917-5857     ISO Abbreviation:  Clin Calcium     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433326     Medline TA:  Clin Calcium     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  355-60     Citation Subset:  IM    
Affiliation:
Laboratory of Cellular Dynamics, Immunology Frontier Research Center, Osaka University, Japan Science and Technology, CREST, Japan.
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