Document Detail


Evaluation of the association between the ADRA2A genetic polymorphisms and type 2 diabetes in a Chinese Han population.
MedLine Citation:
PMID:  23153004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alpha-2-adrenergic receptor (ADRA2A) is involved in the sympathetic nervous system and plays a role in the regulation of insulin secretion and lipolysis. Recent studies have indicated that the ADRA2A polymorphisms are associated with type 2 diabetes (T2DM) in Caucasians and African Americans. The present study aimed to evaluate the association between the ADRA2A polymorphisms and T2DM in a Chinese Han population. Two single-nucleotide polymorphisms (SNPs) rs521674 and rs553668 in the ADRA2A gene were genotyped in 2094 Chinese subjects (1042 T2DM patients and 1052 nondiabetic controls) by using the TaqMan allelic discrimination technique. A single-locus analysis indicated that SNP rs553668 was associated with T2DM (p=0.04). Further analysis indicated that the association of SNP rs553668 was found in T2DM patients with body mass index (BMI)<25 kg/m(2) (p=0.03), but not in the patients with BMI≥25 kg/m(2) (p=0.56). This association was still significant in a recessive model (p=0.01, odds ratio=0.68, 95% confidence interval=0.51-0.92). In conclusion, the present study provides evidence that the ADRA2A polymorphism, rs553668, is associated with lean T2DM patients in a Chinese Han population. Further investigation to explore the role of ADRA2A in the regulation of body weight has been taken into our consideration.
Authors:
Tianjie Li; Xilin Zhu; Xiaopan Wu; Jingyun Li; Liping Pan; Pengtao Li; Zhenhui Xin; Harvest F Gu; Ying Liu
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genetic testing and molecular biomarkers     Volume:  16     ISSN:  1945-0257     ISO Abbreviation:  Genet Test Mol Biomarkers     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-07-22     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  101494210     Medline TA:  Genet Test Mol Biomarkers     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1424-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Asian Continental Ancestry Group*
Blood Glucose / genetics
Diabetes Mellitus, Type 2 / ethnology,  genetics*
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide*
Receptors, Adrenergic, alpha-2 / genetics*
Chemical
Reg. No./Substance:
0/ADRA2A protein, human; 0/Blood Glucose; 0/Receptors, Adrenergic, alpha-2
Comments/Corrections

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