| Evaluation of Arrhythmia Scoring Systems and Exercise Induced Cardioprotection. | |
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MedLine Citation:
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PMID: 21857371 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION:: Exercise is protective against ventricular arrhythmias induced by ischemia (I), the condition of inadequate blood flow, and reperfusion (R), the re-establishment of blood flow. This protection is observed clinically and scientifically by decreased incidence in electrocardiogram (ECG) abnormalities. Numerous scoring systems exist for the quantification of ventricular arrhythmia severity. Based upon pre-ventricular contractions, ventricular tachycardia, and ventricular fibrillation frequency, these scoring systems are intended to provide more robust ECG outcome indicators than individual arrhythmia variables. Scoring systems vary primarily on continuous versus discontinuous treatment of the data, which should be considered when matching these arrhythmia metrics to scientific applications. PURPOSE:: The aim of this investigation was to evaluate 7 ECG scoring systems in the assessment of ventricular arrhythmia severity following IR in male Sprague Dawley rats. METHODS:: Animals remained sedentary or exercised (3 days treadmill exercise for 60 minutes) prior to surgically induced IR. A subset of sedentary animals served as sham, undergoing surgical procedure without IR. ECGs were evaluated under blinded conditions by 3 trained individuals. Single arrhythmia data and the parametric score were analyzed by one-way ANOVA, while the Kruskal-Wallis was used to compare group means for all non-parametric scoring systems between groups. RESULTS:: IR produced a significant arrhythmic response in exercised and sedentary rats as determined by all arrhythmia scoring systems. Four arrhythmia metrics resulted in significant differences between exercised and sedentary treatments (P < 0.001) while 3 metrics did not. CONCLUSION:: Continuous versus discontinuous treatment of the data may account for variation in scoring system outcomes. These data confirm exercise protects against IR induced arrhythmias and care must be taken when selecting an arrhythmia scoring system for ECG evaluation. |
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Authors:
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Lindsey E Miller; Peter A Hosick; Jenna Wrieden; Emily Hoyt; John C Quindry |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-12 |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: - ISSN: 1530-0315 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Department of Kinesiology, Auburn University, Auburn, Alabama 36849 2Department of Health, Leisure and Exercise Science, Appalachian State University, Boone, North Carolina 28608. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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