Document Detail


Evaluation of AMPD1 C34T genotype as a predictor of mortality in heart failure and post-myocardial infarction patients.
MedLine Citation:
PMID:  16875916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The AMPD1 gene C34T polymorphism has previously been associated with prolonged survival in small cohorts of heart failure (HF) and coronary artery disease patients. This study aimed to corroborate the association of the AMPD1 C34T polymorphism with survival in larger myocardial infarction (MI) and HF cohorts. METHODS: Genotypes were obtained for 935 post-MI (PMI) and 433 patients with established HF, with median follow-up times of 5.4 and 3.1 years, respectively. At admission, cardiac function was assessed by nuclear ventriculography (PMI) and echocardiography (HF) and plasma cardiac neurohormones were assayed. RESULTS: Differences in mortality by AMPD1 genotype did not achieve significance, either for the overall HF (P = .07) or the overall PMI group (P = .28), but AMPD1 genotype predicted mortality in patients of both cohorts with a history of MI (HxMI). In contrast to previous studies, the mutant T allele was associated with poorer outcome. Mortality in HF HxMI patients was significantly different between genotype groups (n = 144, mortality CC 56.5%, CT/TT 77.8%, P = .027), but not in patients without HxMI. In PMI patients, the association of genotype with survival in the HxMI subgroup trended toward significance (n = 147, mortality CC 29.8%, CT/TT 45.5%, P = .093). Multivariate analysis of combined PMI and HF cohorts showed that HxMI patients with CT/TT genotype were at greater risk than all other groups (P < .001). CONCLUSION: This study suggests that AMPD1 C34T genotype is not a predictor of survival in heart disease patients, except possibly those with HxMI.
Authors:
Richard P Collins; Barry R Palmer; Anna P Pilbrow; Chris M Frampton; Richard W Troughton; Tim G Yandle; Lorraine Skelton; A Mark Richards; Vicky A Cameron
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  152     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-09-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  312-20     Citation Subset:  AIM; IM    
Affiliation:
Christchurch Cardioendocrine Research Group, Department of Medicine, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
AMP Deaminase / genetics*
Aged
Aldosterone / blood
Angiotensin II / blood
Atrial Natriuretic Factor / blood
Endothelin-1 / blood
Epinephrine / blood
Female
Genotype
Heart Failure / genetics*,  mortality*
Humans
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction / genetics*,  mortality*
Natriuretic Peptide, Brain / blood
Norepinephrine / blood
Polymorphism, Genetic
Proportional Hazards Models
Retrospective Studies
Chemical
Reg. No./Substance:
0/Endothelin-1; 11128-99-7/Angiotensin II; 114471-18-0/Natriuretic Peptide, Brain; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 52-39-1/Aldosterone; 85637-73-6/Atrial Natriuretic Factor; EC 3.5.4.6/AMP Deaminase
Comments/Corrections
Comment In:
Am Heart J. 2007 May;153(5):e15   [PMID:  17452135 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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