Document Detail


Evaluation of a 5-year programme to prevent mother-to-child transmission of HIV infection in Northern Uganda.
MedLine Citation:
PMID:  19602489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out of 19,017 women, 1,037 (5.5%) attending antenatal care services tested HIV positive. Of these, 517 (50%) enrolled in the PMTCT programme and gave birth to 567 infants. Before tracing, 303 (53%) mother-infant pairs were LFU. Reasons for dropout were infant death and lack of understanding of importance of follow-up. Risk of death or LFU was higher among infants with no or incomplete intrapartum prophylaxis (OR = 1.90, 95% CI 1.07-3.36) and of weaning age <6 months (OR 2.55, 95% CI 1.42-4.58), and lower in infants with diagnosed acute illness (OR 0.30, 95% CI 0.16-0.55). Mother-to-child HIV cumulative transmission rate was 8.3%, and 15.5% when HIV-related deaths were considered. Improved tracking of HIV-exposed infants is needed in PMTCT programmes where access to early infant diagnosis is still limited.
Authors:
Laurence Ahoua; Harriet Ayikoru; Katherine Gnauck; Grace Odaru; Emmanuel Odar; Christine Ondoa-Onama; Loretxu Pinoges; Suna Balkan; David Olson; Mar Pujades-Rodr?guez
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-13
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  56     ISSN:  1465-3664     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-25     Completed Date:  2010-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-52     Citation Subset:  IM    
Affiliation:
Epicentre, Paris, France. laurence.ahoua@epicentre.msf.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-HIV Agents / therapeutic use*
Counseling
Female
HIV Infections / drug therapy,  prevention & control,  transmission*
HIV-1
Humans
Infectious Disease Transmission, Vertical / prevention & control*,  statistics & numerical data
Kaplan-Meiers Estimate
Male
Middle Aged
Mothers
Postnatal Care / utilization
Pregnancy
Pregnancy Complications, Infectious / drug therapy*,  epidemiology
Prenatal Care
Retrospective Studies
Rural Population
Treatment Outcome
Uganda / epidemiology
Young Adult
Chemical
Reg. No./Substance:
0/Anti-HIV Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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