| Evaluation of a 5-year programme to prevent mother-to-child transmission of HIV infection in Northern Uganda. | |
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MedLine Citation:
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PMID: 19602489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out of 19,017 women, 1,037 (5.5%) attending antenatal care services tested HIV positive. Of these, 517 (50%) enrolled in the PMTCT programme and gave birth to 567 infants. Before tracing, 303 (53%) mother-infant pairs were LFU. Reasons for dropout were infant death and lack of understanding of importance of follow-up. Risk of death or LFU was higher among infants with no or incomplete intrapartum prophylaxis (OR = 1.90, 95% CI 1.07-3.36) and of weaning age <6 months (OR 2.55, 95% CI 1.42-4.58), and lower in infants with diagnosed acute illness (OR 0.30, 95% CI 0.16-0.55). Mother-to-child HIV cumulative transmission rate was 8.3%, and 15.5% when HIV-related deaths were considered. Improved tracking of HIV-exposed infants is needed in PMTCT programmes where access to early infant diagnosis is still limited. |
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Authors:
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Laurence Ahoua; Harriet Ayikoru; Katherine Gnauck; Grace Odaru; Emmanuel Odar; Christine Ondoa-Onama; Loretxu Pinoges; Suna Balkan; David Olson; Mar Pujades-Rodr?guez |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-13 |
Journal Detail:
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Title: Journal of tropical pediatrics Volume: 56 ISSN: 1465-3664 ISO Abbreviation: J. Trop. Pediatr. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-25 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010948 Medline TA: J Trop Pediatr Country: England |
Other Details:
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Languages: eng Pagination: 43-52 Citation Subset: IM |
Affiliation:
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Epicentre, Paris, France. laurence.ahoua@epicentre.msf.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-HIV Agents / therapeutic use* Counseling Female HIV Infections / drug therapy, prevention & control, transmission* HIV-1 Humans Infectious Disease Transmission, Vertical / prevention & control*, statistics & numerical data Kaplan-Meiers Estimate Male Middle Aged Mothers Postnatal Care / utilization Pregnancy Pregnancy Complications, Infectious / drug therapy*, epidemiology Prenatal Care Retrospective Studies Rural Population Treatment Outcome Uganda / epidemiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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