| Evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for ursodeoxycholic acid, and 7 oxo- and 12 oxo- bile acids. | |
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MedLine Citation:
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PMID: 6929859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3 alpha-Hydroxysteroid dehydrogenase (SDH) quantifies ursodeoxycholic acid, 3 alpha,12 alpha-diol-7-one-5 beta-cholanoic acid, 3 alpha-ol-7-one-5 beta-cholanoic acid, and 3 alpha,7 alpha-diol-12-one-5 beta-cholanoic acid in a manner similar to the more commonly measured bile acids, exemplified by taurocholic acid. The type of oxygen function at the 7 or 12 position and its orientation at the 7 position has no effect on the rate of reaction of the enzyme. Discrepancies in the glycine/taurine ratios of patient intestinal aspirates containing ursodeoxycholic acid and oxo bile acids, obtained by SDH and gas-liquid chromatographic methods are not a result of the enzyme assay procedure. |
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Authors:
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L J Haeffner; S J Gordon; J S Magen; O D Kowlessar |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of lipid research Volume: 21 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1980 May |
Date Detail:
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Created Date: 1980-08-28 Completed Date: 1980-08-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 477-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxysteroid Dehydrogenases* Bile / analysis Bile Acids and Salts / analysis Chenodeoxycholic Acid / analogs & derivatives, analysis Cholic Acids / analysis* Chromatography, Gas Deoxycholic Acid / analogs & derivatives*, analysis Glycine / analysis Humans Intestines / analysis Lithocholic Acid / analogs & derivatives, analysis Taurine / analysis Ursodeoxycholic Acid / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Cholic Acids; 107-35-7/Taurine; 128-13-2/Ursodeoxycholic Acid; 2458-08-4/3,7-dihydroxy-12-oxocholanoic acid; 434-13-9/Lithocholic Acid; 4651-67-6/7-ketolithocholic acid; 474-25-9/Chenodeoxycholic Acid; 56-40-6/Glycine; 83-44-3/Deoxycholic Acid; 911-40-0/7-ketodeoxycholic acid; EC 1.1.-/3-Hydroxysteroid Dehydrogenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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