Document Detail


Evaluation of (241)Am deposited in different parts of the leg bones and skeleton to justify in vivo measurements of the knee for estimating total skeletal activity.
MedLine Citation:
PMID:  23192087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The percentage of Am deposited in different parts of leg bones relative to the total leg activity was calculated from radiochemical analysis results from six whole body donors participating in the U.S. Transuranium and Uranium Registries (USTUR). In five of these six USTUR cases, the percentage of Am deposited in the knee region as well as in the entire leg was separately calculated relative to total skeletal activity. The purpose of this study is to find a region in the leg that is both suitable for in vivo measurement of Am deposited in the bones and has a good correlation with the total skeletal Am burden. In all analyzed cases, the femur was the bone with the highest percentage of Am deposited in the leg (48.8%). In the five cases that have complete whole skeletal analysis, the percentage of Am activity in the knee relative to entire skeletal activity was 4.8%, and the average value of its coefficient of variation was 10.6%. The percentage of Am in the leg relative to total skeletal activity was 20% with an average coefficient of variation of 13.63%. The Am activity in the knee as well as in the leg was strongly correlated (R = 99.5% and R = 99.1%, respectively) with the amount of Am activity in the entire skeleton using a simple linear relationship. The highest correlation was found between the amount of Am deposited in the knee and the amount of Am deposited in the entire skeleton. This correlation is important because it might enable an accurate assessment of the total skeletal Am burden to be performed from in vivo monitoring of the knee region. In all analyzed cases, an excellent correlation (R = 99.9%) was found between the amount of Am activity in the knee and the amount of Am activity in the entire leg. The results of this study suggest three simple models: two models to predict the total skeletal activity based on either leg or knee activity, and the third model to predict the total leg activity based on knee activity. The results also suggest that the knee region is a suitable position for in vivo measurements of Am deposited in the bones and also for an accurate and efficient detection system. Detector efficiency should be apparently calibrated based on only the Am burden in the knee region bones instead of Am activity deposited in the entire leg.
Authors:
Majid Khalaf; Richard R Brey; DeWayne Derryberry
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Health physics     Volume:  104     ISSN:  1538-5159     ISO Abbreviation:  Health Phys     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-29     Completed Date:  2013-03-20     Revised Date:  2013-03-25    
Medline Journal Info:
Nlm Unique ID:  2985093R     Medline TA:  Health Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-62     Citation Subset:  IM    
Affiliation:
Idaho State University, Nuclear Engineering and Health Physics, P.O. Box 8106, Pocatello ID 83209, USA. khalmaji@isu.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Americium / analysis*
Humans
Knee / radiation effects
Leg Bones / chemistry*
Male
Radiation Monitoring
Chemical
Reg. No./Substance:
7440-35-9/Americium
Comments/Corrections
Erratum In:
Health Phys. 2013 Mar;104(3):336

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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