| Evaluation of 18FDG PET-CT in the Diagnosis of Endometriosis: A Prospective Study. | |
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MedLine Citation:
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PMID: 21285451 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Noninvasive techniques have poor sensitivity and specificity in diagnosing endometriosis, which is often associated with an inflammatory process. In several benign diseases, measurement of hypermetabolism using fluorodeoxyglucose ((18)F (18)FDG) reflects the degree of inflammation and aggressiveness of the disease. This prospective study evaluated the value of (18)FDG positron emission tomography (PET)-computed tomography (CT) in assessing the presence of endometriosis. Methods: Ten consecutive patients suspected with endometriosis were prospectively included in this study. A preoperative (18)FDG PET-CT was performed in all the patients during the follicular phase of their cycle, which preceded laparoscopic surgery. Surgical endometriosis staging and histopathological analysis of removed tissue were confronted with the results from (18)FDG PET-CT. Results: Of the 10 patients, 9 had endometriosis confirmed by laparoscopy; 6 had advanced stage of the disease and 5 had histologically proven lesions. Nevertheless, none of the patients had (18)FDG-demonstrated hypermetabolism at PET-CT. Conclusions: In this preliminary series, we did not observe hypermetabolic activity in relation to endometriosis using (18)FDG PET-CT. This study's most important limitation is the use of (18)FDG as an isotopic tracer, which is not specific to endometrial tissue. |
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Authors:
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Maxime Fastrez; C Nogarède; M Tondeur; N Sirtaine; S Rozenberg |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-1 |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: - ISSN: 1933-7205 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Obstetrics and Gynaecology, CHU St Pierre, Université Libre de Bruxelles, Brussels, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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