| Evaluation of (18)F-FDG PET/CT and CT/MRI with Histopathologic Correlation in Patients Undergoing Salvage Surgery for Head and Neck Squamous Cell Carcinoma. | |
| | |
MedLine Citation:
|
PMID: 21409485 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: (18)F-fludeoxyglucose (FDG) positron emission tomography (PET) is a sensitive and specific method for detecting active residual disease after chemoradiotherapy or radiotherapy, but few studies have accurately evaluated its diagnostic accuracy with histopathologic correlation. We therefore investigated the clinical utility of (18)F-FDG PET/computed tomography (CT) in patients undergoing salvage surgery for residual head and neck squamous cell carcinoma (HNSCC) after primary nonsurgical treatments. METHODS: Thirty-nine patients who initially received chemotherapy (n = 23), radiotherapy (n = 3), or chemoradiotherapy (n = 13) were evaluated 8-28 weeks later by (18)F-FDG PET/CT and CT/magnetic resonance imaging (MRI) prior to salvage surgery to clear residual disease. These results were compared with those of histopathologic analysis of the primary tumor and neck dissection tissue samples. RESULTS: Of these 39 patients, 22 (56%) had residual primary tumor. The sensitivity, specificity and accuracy of (18)F-FDG PET/CT for detecting primary tumors were 91, 65, and 79%, respectively. Of 56 dissected heminecks, 37 (66%) had residual metastatic lymph nodes. (18)F-FDG PET/CT and CT/MRI had accuracies for positive heminecks of 91 and 75%, respectively (P = 0.004). On a cervical level-by-level-based analysis, (18)F-FDG PET/CT and CT/MRI had accuracies of 89 and 78%, respectively (P < 0.001); (18)F-FDG PET/CT had a specificity of 93% and a negative-predictive value of 92% for detection of positive levels. CONCLUSIONS: (18)F-FDG PET/CT is superior to CT/MRI in detecting residual nodal disease in head and neck squamous cell carcinoma patients undergoing salvage surgery. Accurate preoperative diagnosis using (18)F-FDG PET/CT may help to determine the extent of salvage surgery. |
| | |
Authors:
|
Sang Yoon Kim; Jae Seung Kim; Jong Sook Yi; Jeong Hyun Lee; Seung-Ho Choi; Soon Yuhl Nam; Kyung-Ja Cho; Sang-Wook Lee; Sung-Bae Kim; Jong-Lyel Roh |
Related Documents
:
|
16871715 - Mr imaging and osteoporosis: fractal lacunarity analysis of trabecular bone. 2941205 - Bone imaging of sternocostoclavicular hyperostosis in palmoplantar pustulosis. 22378755 - Diagnostic accuracy on fat-saturated t2 weighted mri for diagnosis of intra-articular a... 22224355 - Transient cortical blindness post angiography--a case report. 10222425 - Aggressive giant pituitary adenoma presenting as a nasopharyngeal mass: magnetic resona... 21187685 - Clinical application of mr spectroscopy and imaging of brain tumor. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-16 |
Journal Detail:
|
Title: Annals of surgical oncology Volume: - ISSN: 1534-4681 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9420840 Medline TA: Ann Surg Oncol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interrelationships between Tumor Proliferative Activity, Leucocyte and Macrophage Infiltration, Syst...
Next Document: Two-Stage Operation for High-Risk Patients with Thoracic Esophageal Cancer: An Old Operation Revisit...