| Evaluation of (18)F-FDG PET-CT for differentiation of pulmonary pathology in an approach of outpatient fast track assessment. | |
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MedLine Citation:
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PMID: 19687763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The aim of our study was to evaluate the clinical performance/ implementation of integrated F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) for differentiation of pulmonary pathology in an approach of outpatient fast track assessment. METHODS: A prospective study was performed in 114 consecutive patients with pulmonary symptoms and/or abnormal chest x-ray were referred for fast track assessment to the Netherlands Cancer Institute from March 2005 to September 2007. The presence of malignancy was evaluated in a multidisciplinary setting, including F-fluorodeoxyglucose-PET, diagnostic CT, and bronchoscopy (including biopsy), with histopathological evaluation as the reference standard. RESULTS: In 105 patients (92%), a final diagnosis was achieved. A malignancy was diagnosed in 84% of the patients; non-small cell lung cancer in 67%, small cell lung cancer in 7%, and metastases or other malignancies in 10%. Nonmalignant lesions were found in 16% of the patients. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of positive PET/CT for the presence of malignancy were 97, 56, 90, 92, and 77%, respectively. PET/CT showed unexpected M1 disease (not detected on CT) in 10% of the patients. Almost half of the patients with a malignancy were scheduled for curative treatment, of whom 29 patients for surgery and 14 patients for chemoradiotherapy. CONCLUSION: In this outpatient fast track setting, PET/CT provides valuable information for diagnosing lung cancer, with a high positive predictive value, and is useful for clinical decision making. |
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Authors:
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Tjeerd S Aukema; Renato A Vald?s Olmos; Houke M Klomp; Hendrik J Teertstra; Jos? S A Belderbos; Wouter V Vogel; Paul Baas; Sjaak A Burgers; Michel M van den Heuvel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Volume: 4 ISSN: 1556-1380 ISO Abbreviation: J Thorac Oncol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-03-04 Completed Date: 2010-05-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101274235 Medline TA: J Thorac Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 1226-30 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. t.aukema@nki.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Non-Small-Cell Lung
/
pathology,
radiography,
radionuclide imaging Diagnosis, Differential Female Fluorodeoxyglucose F18 / diagnostic use* Humans Lung Neoplasms / pathology, radiography*, radionuclide imaging* Male Middle Aged Neoplasm Metastasis Neoplasm Staging Positron-Emission Tomography* Prognosis Prospective Studies Radiopharmaceuticals / diagnostic use* Sensitivity and Specificity Small Cell Lung Carcinoma / pathology, radionuclide imaging, therapy Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
Comment In:
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J Thorac Oncol. 2009 Oct;4(10):1192-4
[PMID:
20197732
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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