| Evaluation of 188Re-DTPA-deoxyglucose as a potential cancer radiopharmaceutical. | |
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MedLine Citation:
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PMID: 20173156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We aimed to synthesize diethylenetriamine pentaacetic acid-deoxyglucose (DTPA-DG) radiolabeled with (188)Re and to evaluate its biologic characteristics using mammary tumor-bearing mice. MATERIALS AND METHODS: The biodistribution of the radiolabeled compound was determined by tissue counting at 3, 12, and 24 hours after injection in experimental animals. Scintigraphic examinations of nude mice bearing breast cancer (MCF-7 cells) were performed after (188)Re-DTPA-DG (18.5 MBq) was injected in the tail vein. For the tumor inhibitory portion of this work, tumor volumes were measured and recorded every 3 days until the 21st day after injection. RESULTS: The radiochemical purity of (188)Re-DTPA-DG was 95.0%. Based on biodistribution measurements, (188)Re-DTPA-DG was taken up at high levels by the tumor. The mean tumoral percent injected dosages per gram (% ID/g) were 1.98 +/- 0.29 (SD), 2.89 +/- 0.43, and 0.42 +/- 0.06 % ID/g at 3, 12, and 24 hours, respectively, after injection. In the (188)Re-DTPA-DG scintigraphic examinations, the tumors were clearly delineated on the images recorded 2, 4, 8, 12, and 24 hours after injection. In the tumor inhibitory evaluations, the tumor volume of the (188)Re-DTPA-DG-treated group increased more slowly than that of the control groups, which were treated with (188)Re-perrhenate or saline (p < 0.01). Rhenium-188-DTPA-DG showed excellent tumor targeting and tumor growth suppression properties on MCF-7 tumor cells. CONCLUSION: Rhenium-188-DTPA-DG may be a potential agent for the diagnosis and radiotherapy of tumors. |
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Authors:
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Yue Chen; Qing-Feng Xiong; Xi-Qun Yang; Ling He; Zhan-Wen Huang |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 194 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 761-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Nuclear Medicine, Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan 646000, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Deoxyglucose / analogs & derivatives*, chemistry, diagnostic use, pharmacokinetics Female Mammary Neoplasms, Animal / radionuclide imaging* Mice Mice, Nude Pentetic Acid / analogs & derivatives*, chemistry, diagnostic use, pharmacokinetics Radiopharmaceuticals / chemistry, diagnostic use*, pharmacokinetics Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/188Re-DTPA-deoxyglucose; 0/Radiopharmaceuticals; 154-17-6/Deoxyglucose; 67-43-6/Pentetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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