Document Detail


Evaluating targets for control of plasmid-mediated antimicrobial resistance in enteric commensals of beef cattle: a modelling approach.
MedLine Citation:
PMID:  23339899     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SUMMARY Enteric commensal bacteria of food animals may serve as a reservoir of genes encoding antimicrobial resistance (AMR). The genes are often plasmidic. Different aspects of bacterial ecology can be targeted by interventions to control plasmid-mediated AMR. The field efficacy of interventions remains unclear. We developed a deterministic mathematical model of commensal Escherichia coli in its animate and non-animate habitats within a beef feedlot's pen, with some E. coli having plasmid-mediated resistance to the cephalosporin ceftiofur. We evaluated relative potential efficacy of within- or outside-host biological interventions delivered throughout rearing depending on the targeted parameter of bacterial ecology. Most instrumental in reducing the fraction of resistant enteric E. coli at steer slaughter age were interventions acting on the enteric E. coli and capable of either 'plasmid curing' E. coli, or lowering maximum E. coli numbers or the rate of plasmid transfer in this habitat. Also efficient was to increase the regular replacement of enteric E. coli. Lowering replication rate of resistant E. coli alone was not an efficient intervention target.
Authors:
V V Volkova; Z Lu; C Lanzas; Y T Grohn
Related Documents :
24168419 - Effect of chain elongation on biological properties of the toxin paralysin β-alanyl-ty...
24557749 - Current biotechnological applications of the genus amycolatopsis.
24617729 - Rice ospad4 functions differently from arabidopsis atpad4 in host-pathogen interactions.
24627729 - Essential oils, a new horizon in combating bacterial antibiotic resistance.
24308379 - Genetic architecture of resistance to septoria tritici blotch in european wheat.
22483399 - Typing of lactobacillus sanfranciscensis isolates from traditional sourdoughs by combin...
4418209 - Metabolism of benzoate and the methylbenzoates by pseudomonas putida (arvilla) mt-2: ev...
798179 - Effects of different levels of chlortetracycline in the diet of turkey poults artifical...
17827299 - Interplay between the temperate phages py54 and n15, linear plasmid prophages with cova...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  Epidemiology and infection     Volume:  -     ISSN:  1469-4409     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-19     Citation Subset:  -    
Affiliation:
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in mic...
Next Document:  Multi-atlas based segmentation using probabilistic label fusion with adaptive weighting of image sim...