| Evaluating the safety of St. John's Wort in human pregnancy. | |
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MedLine Citation:
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PMID: 19491000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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St. John's Wort is a herbal therapy, shown to be effective in treating mild to moderate depression; a disease common in women in their childbearing years. With a significant proportion of unplanned pregnancies, exposure to St. John's Wort into pregnancy is expected to occur. The purpose of this study was to determine whether exposure to this agent in pregnancy is associated with major malformations. We prospectively collected and followed subjects taking St. John's Wort and compared them to a matched group of pregnant women taking other pharmacologic therapy for depression and a third group of healthy women, not exposed to any known teratogens. We obtained follow-up information on 54 St. John's Wort exposed pregnancies and 108 pregnancies in the two comparator groups. Our results indicated that the rates of major malformations were similar across the three groups, with 5%, 4% and 0% in the St. John's Wort, disease comparator, and health group, respectively (p=0.26), This was not different that the 3-5% risk expected in the general population. The live birth and prematurity rates were also not different among the three groups. Though further large scale studies are still needed, this first study on the effects of St. John's Wort in human pregnancy does provide some evidence of fetal safety. |
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Authors:
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Myla E Moretti; Ashley Maxson; Fionna Hanna; Gideon Koren |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-24 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 28 ISSN: 1873-1708 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-03 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 96-9 Citation Subset: IM |
Affiliation:
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The Motherisk Program, Division of Clinical Pharmacology & Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada. momrisk@sickkids.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology* Adult Antidepressive Agents / adverse effects* Birth Weight / drug effects Case-Control Studies Consumer Product Safety Depression / drug therapy* Female Humans Hypericum* Live Birth Plant Preparations / adverse effects Pregnancy Pregnancy Complications / drug therapy* Premature Birth / chemically induced Prospective Studies Risk Assessment |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Plant Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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