| Evaluating the role of serum elastase 1 in the diagnosis of pancreatic cancer. | |
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MedLine Citation:
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PMID: 16643340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the normal value of serum elastase 1 in Chinese adults and evaluate its diagnostic value for pancreatic cancer. METHODS: Serum elastase 1 and CA19-9 were measured in 132 samples, including 39 patients with pancreatic cancer, 48 with other gastrointestinal malignancy, 24 with gastrointestinal benign disease and 21 healthy adults as normal control. Multiple statistical methods including receiver operating characteristics curve and discriminant analysis were employed. RESULTS: The established normal range of serum elastase 1 in Chinese adults was found to be under 4.36 mg/L. Serum elastase 1 increased markedly in patients with pancreatic carcinoma of smaller size and/or located in the pancreatic head. The sensitivity, specificity and overall accuracy of elastase 1 for diagnosis of pancreatic cancer were 61.5%, 75.3% and 71.2%, respectively, as compared with 71.8%, 73.1% and 72.7% for CA19-9. Discriminant analysis can improve the sensitivity and overall accuracy of elastase 1 to 82.0% and 74.2%, respectively, with a slight decline in the specificity to 71.0%. CONCLUSIONS: The cutoff value of serum elastase 1 in normal Chinese adults is 4.36 mg/L. Serum elastase 1 is effective in the diagnosis of pancreatic cancer, especially for those of smaller size or in the pancreatic head. Use of appropriate statistical methods can help to make the diagnosis more accurate. |
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Authors:
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Dong Wu; Jia Ming Qian; Rui Xue Deng; Wei Jun Jiang; Yuan Jia Chen; Xiao Hong Liu; Xing Hua Lu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chinese journal of digestive diseases Volume: 7 ISSN: 1443-9611 ISO Abbreviation: Chin J Dig Dis Publication Date: 2006 |
Date Detail:
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Created Date: 2006-04-28 Completed Date: 2006-12-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101088612 Medline TA: Chin J Dig Dis Country: Australia |
Other Details:
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Languages: eng Pagination: 117-20 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over CA-19-9 Antigen / blood Case-Control Studies Clinical Enzyme Tests Discriminant Analysis Female Gastrointestinal Neoplasms / diagnosis, enzymology Humans Male Middle Aged Pancreatic Elastase / blood* Pancreatic Neoplasms / diagnosis*, enzymology* Sensitivity and Specificity Tumor Markers, Biological / blood* |
| Chemical | |
Reg. No./Substance:
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0/CA-19-9 Antigen; 0/Tumor Markers, Biological; EC 3.4.21.36/Pancreatic Elastase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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