Document Detail


Evaluating the role of biomarkers for cardiovascular risk prediction: focus on CRP, BNP and urinary microalbumin.
MedLine Citation:
PMID:  18020909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular disease is a significant cause of morbidity and mortality, making cardiovascular prevention an important public health goal. The use of cardiac biomarkers represents a potential, noninvasive method to identify asymptomatic individuals who are most likely to develop cardiovascular disease. Several known biomarkers predict cardiovascular risk above and beyond conventional risk factors. Nonetheless, available evidence suggests that current biomarkers do not have sufficient sensitivity or specificity to justify widespread use for cardiovascular risk prediction. New developments in molecular biology and genetics may allow the identification of additional biomarkers, likely acting via different pathways, to achieve this goal.
Authors:
Abigail May; Thomas J Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert review of molecular diagnostics     Volume:  7     ISSN:  1744-8352     ISO Abbreviation:  Expert Rev. Mol. Diagn.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120777     Medline TA:  Expert Rev Mol Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  793-804     Citation Subset:  IM    
Affiliation:
Massachusetts General Hospital, Department of Internal Medicine Harvard Medical School, Boston, MA 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Albuminuria*
Animals
Area Under Curve
Biological Markers / blood*
C-Reactive Protein* / diagnostic use,  metabolism
Cardiovascular Diseases* / diagnosis,  metabolism,  mortality
Humans
Inflammation / diagnosis,  metabolism
Natriuretic Peptide, Brain* / blood,  diagnostic use
Predictive Value of Tests
Risk Factors
Grant Support
ID/Acronym/Agency:
K23-HL-074077/HL/NHLBI NIH HHS; R01-HL-083197/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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