| Evaluating the non-tuberculous mycobacteria effect in the tuberculosis infection diagnosis. | |
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MedLine Citation:
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PMID: 20123845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to determine the role of previous non-tuberculous mycobacteria sensitisation in children as a factor of discordant results between tuberculin skin test (TST) and an in vitro T-cell based assay (T-SPOT.TB; Oxford Immunotec, Oxford, UK). We enrolled 21 non-bacille Calmette-Guérin-vaccinated paediatric patients for suspicious of latent tuberculosis infection (LTBI). These patients yielded a positive TST and a negative T-SPOT.TB. Cells were stimulated with Mycobacterium avium sensitin (having cross-reaction with Mycobacterium intracellulare and Mycobacterium scrofulaceum) and the presence of reactive T-cells was determined by an ex vivo ELISPOT. From the 21 patients, in 10 cases (47.6%), we obtained a positive ELISPOT result after stimulation with M. avium sensitin, in six (28.6%) cases, the result was negative and in the remaining five (23.8%) cases, the result was indeterminate. In conclusion, previous non-tuberculous mycobacteria sensitisation induces false-positive results in the TST for diagnosing LTBI and the use of gamma-interferon tests could avoid unnecessary chemoprophylaxis treatment among a child population. |
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Authors:
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I Latorre; M De Souza-Galvão; J Ruiz-Manzano; A Lacoma; C Prat; N Altet; V Ausina; J Domínguez |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The European respiratory journal Volume: 35 ISSN: 1399-3003 ISO Abbreviation: Eur. Respir. J. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-11-16 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 338-42 Citation Subset: IM |
Affiliation:
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Servei de Microbiologia, Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Carretera del Canyet s/n, 08916 Badalona Barcelona Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Bacterial Infections Case-Control Studies Child Child, Preschool Female Humans Interferon-gamma / metabolism Latent Tuberculosis Male Mycobacterium / metabolism* Mycobacterium avium / immunology* Retrospective Studies Tuberculin Test / methods Tuberculosis / diagnosis*, microbiology* |
| Chemical | |
Reg. No./Substance:
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82115-62-6/Interferon-gamma |
| Comments/Corrections | |
Comment In:
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Eur Respir J. 2010 Jul;36(1):214-5; author reply 215-6
[PMID:
20595171
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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