Document Detail

Evaluating the neural basis of temporal order memory for visual stimuli in the rat.
MedLine Citation:
PMID:  21226775     Owner:  NLM     Status:  MEDLINE    
Temporal order memory (memory for stimulus order) is crucial for discrimination between familiar objects and depends upon a neural circuit involving the perirhinal cortex (PRH) and medial pre-frontal cortex. This study examined the role of glutamatergic and cholinergic neurotransmission in the encoding or retrieval of temporal order memory, using a task requiring the animals to discriminate between two familiar objects presented at different intervals. 6-Cyano-7-nitroquinoxaline (CNQX) (AMPA/kainate receptor antagonist), scopolamine (muscarinic receptor antagonist) or 2-amino-5-phosphonopentanoic acid (AP5) (N-methyl-D-aspartate receptor antagonist) was administered before sample phase 2 (to be active during encoding) or before test (to be active during retrieval). Unilateral CNQX administration into the PRH and pre-limbic/infra-limbic cortices (PL/IL) in opposite hemispheres, i.e. to disrupt neurotransmission within the circuit, impaired encoding and retrieval. Administration of scopolamine or AP5 in the PRH-PL/IL circuit impaired encoding. Drug effects in each brain region were then investigated separately. Intra-PRH CNQX, scopolamine or AP5 disrupted encoding, such that the animals explored the recent object significantly more than the old object. In contrast, intra-PL/IL CNQX, scopolamine or AP5 impaired memory performance such that the animals spent an equal amount of time exploring the objects. CNQX but not AP5 or scopolamine impaired retrieval. Furthermore, CNQX impaired novel object preference when infused into the PRH but not PL/IL following a 3 h delay. Thus, encoding of temporal order memory is mediated by plastic processes involving N-methyl-D-aspartate and muscarinic receptors within the PRH-PL/IL circuit, but these two regions make qualitatively different cognitive contributions to the formation of this memory process.
G R I Barker; E C Warburton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-13
Journal Detail:
Title:  The European journal of neuroscience     Volume:  33     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-05-31     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  705-16     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
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MeSH Terms
6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
Behavior, Animal
Brain / anatomy & histology,  metabolism
Cholinergic Antagonists / pharmacology
Discrimination (Psychology) / physiology
Excitatory Amino Acid Antagonists / pharmacology
Memory / drug effects,  physiology*
Photic Stimulation*
Scopolamine Hydrobromide / pharmacology
Synaptic Transmission / physiology
Time Factors
Valine / analogs & derivatives,  pharmacology
Grant Support
BB/E010407/1//Biotechnology and Biological Sciences Research Council; //Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Cholinergic Antagonists; 0/Excitatory Amino Acid Antagonists; 451IFR0GXB/Scopolamine Hydrobromide; 6OTE87SCCW/6-Cyano-7-nitroquinoxaline-2,3-dione; 76326-31-3/2-amino-5-phosphopentanoic acid; HG18B9YRS7/Valine

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