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Evaluating iron status and the risk of anemia in young infants using erythrocyte parameters.
MedLine Citation:
PMID:  23168578     Owner:  NLM     Status:  Publisher    
Background:Correct evaluation of iron status is important in young infants, as both iron deficiency and excess may have negative effects on development, growth and morbidity.Methods:We evaluated iron status by using erythrocyte parameters, including reticulocyte hemoglobin content (CHr) in infants with birth weight <3000 grams (g) (n=80). Blood samples and infant's characteristics were recorded at 6 weeks, 4 and 6 months. Infants with a birth weight ≤2500 g (n=36) were recommended iron supplementation.Results:Despite a significantly poorer status at 6 weeks, iron supplemented infants had significantly higher hemoglobin level (Hb): 12.2 (SD 0.8) and CHr: 28.3 (SD 1.4) at 6 months, compared to non-supplemented infants, Hb: 11.7 (SD 1.0) g/dl, p=0.02 and CHr: 26.5 (SD 2.5) pg, p<0.001. Prolonged exclusive breastfeeding, high weight gain and male gender were predisposing factors for a low iron status at 6 months. A CHr cut-off level of 26.9 pg at 4 months, proved to be a sensitive predictor for anemia at 6 months.Discussion:Signs of an iron-restricted erythropoiesis were observed in non-supplemented infants (birth weight 2501-3000g), and CHr was a useful tool for evaluating iron status. The need for iron supplementation in certain infant risk populations should be further evaluated.Pediatric Research (2012); doi:10.1038/pr.2012.162.
Ingrid Kristin Torsvik; Trond Markestad; Per Magne Ueland; Roy M Nilsen; Oivind Midttun; Anne-Lise Bjørke Monsen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-20
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
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