| Evaluating iron status and the risk of anemia in young infants using erythrocyte parameters. | |
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MedLine Citation:
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PMID: 23168578 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background:Correct evaluation of iron status is important in young infants, as both iron deficiency and excess may have negative effects on development, growth and morbidity.Methods:We evaluated iron status by using erythrocyte parameters, including reticulocyte hemoglobin content (CHr) in infants with birth weight <3000 grams (g) (n=80). Blood samples and infant's characteristics were recorded at 6 weeks, 4 and 6 months. Infants with a birth weight ≤2500 g (n=36) were recommended iron supplementation.Results:Despite a significantly poorer status at 6 weeks, iron supplemented infants had significantly higher hemoglobin level (Hb): 12.2 (SD 0.8) and CHr: 28.3 (SD 1.4) at 6 months, compared to non-supplemented infants, Hb: 11.7 (SD 1.0) g/dl, p=0.02 and CHr: 26.5 (SD 2.5) pg, p<0.001. Prolonged exclusive breastfeeding, high weight gain and male gender were predisposing factors for a low iron status at 6 months. A CHr cut-off level of 26.9 pg at 4 months, proved to be a sensitive predictor for anemia at 6 months.Discussion:Signs of an iron-restricted erythropoiesis were observed in non-supplemented infants (birth weight 2501-3000g), and CHr was a useful tool for evaluating iron status. The need for iron supplementation in certain infant risk populations should be further evaluated.Pediatric Research (2012); doi:10.1038/pr.2012.162. |
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Authors:
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Ingrid Kristin Torsvik; Trond Markestad; Per Magne Ueland; Roy M Nilsen; Oivind Midttun; Anne-Lise Bjørke Monsen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-20 |
Journal Detail:
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Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics, Haukeland University Hospital, Bergen, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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