Document Detail

Evaluating iodine deficiency in pregnant women and young infants-complex physiology with a risk of misinterpretation.
MedLine Citation:
PMID:  18053278     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review methods for evaluating iodine deficiency in pregnant women and young infants and to discuss factors to be considered in the interpretation of their results.
DESIGN: Review of the literature regarding the various methods available for assessing iodine status.
SETTING: Population surveys and research studies.
SUBJECTS: Pregnant women and young infants.
RESULTS: Several factors to consider when assessing iodine status in pregnant women and young infants include: 1) the urinary iodine (UI) concentration (microg l-1) is not interchangeable with 24 h UI excretion (microg per 24 h); 2) the concentration of iodine in a spot or casual urine sample cannot be used to diagnose iodine deficiency in an individual; 3) a moderate fall in the concentration of serum free T4 during pregnancy is not a sign of maternal iodine deficiency; 4) an increase in the concentration of serum thyroglobulin (Tg) during pregnancy is not a sign of maternal iodine deficiency; 5) a higher concentration of TSH and Tg in cord blood than in maternal blood is not a sign of iodine deficiency in the mother or neonate; and 6) thyroid function in a full-term foetus, a neonate or a small child is not more sensitive to a mild iodine deficiency than in the mother.
CONCLUSIONS: If the iodine status of pregnant women and small children is not to be misjudged, the above six factors need to be taken into account.
P Laurberg; S Andersen; R I Bjarnadóttir; A Carlé; Ab Hreidarsson; N Knudsen; L Ovesen; Ib Pedersen; Lb Rasmussen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Public health nutrition     Volume:  10     ISSN:  1368-9800     ISO Abbreviation:  Public Health Nutr     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-04-15     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9808463     Medline TA:  Public Health Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1547-52; discussion 1553     Citation Subset:  IM    
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MeSH Terms
Fetal Blood / chemistry
Infant, Newborn
Iodine / blood,  deficiency*,  metabolism*,  urine
Nutrition Assessment*
Nutritional Status*
Pregnancy Complications / blood,  epidemiology
Sensitivity and Specificity
Thyroid Gland / physiology*
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
Reg. No./Substance:
06LU7C9H1V/Triiodothyronine; 9002-71-5/Thyrotropin; 9679TC07X4/Iodine; Q51BO43MG4/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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