| Evaluating iodine deficiency in pregnant women and young infants-complex physiology with a risk of misinterpretation. | |
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MedLine Citation:
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PMID: 18053278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review methods for evaluating iodine deficiency in pregnant women and young infants and to discuss factors to be considered in the interpretation of their results. DESIGN: Review of the literature regarding the various methods available for assessing iodine status.Setting: Population surveys and research studies. SUBJECTS: Pregnant women and young infants. RESULTS: Several factors to consider when assessing iodine status in pregnant women and young infants include: 1) the urinary iodine (UI) concentration (microg l-1) is not interchangeable with 24 h UI excretion (microg per 24 h); 2) the concentration of iodine in a spot or casual urine sample cannot be used to diagnose iodine deficiency in an individual; 3) a moderate fall in the concentration of serum free T4 during pregnancy is not a sign of maternal iodine deficiency; 4) an increase in the concentration of serum thyroglobulin (Tg) during pregnancy is not a sign of maternal iodine deficiency; 5) a higher concentration of TSH and Tg in cord blood than in maternal blood is not a sign of iodine deficiency in the mother or neonate; and 6) thyroid function in a full-term foetus, a neonate or a small child is not more sensitive to a mild iodine deficiency than in the mother. CONCLUSIONS: If the iodine status of pregnant women and small children is not to be misjudged, the above six factors need to be taken into account. |
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Authors:
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P Laurberg; S Andersen; R I Bjarnadóttir; A Carlé; Ab Hreidarsson; N Knudsen; L Ovesen; Ib Pedersen; Lb Rasmussen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Public health nutrition Volume: 10 ISSN: 1368-9800 ISO Abbreviation: Public Health Nutr Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9808463 Medline TA: Public Health Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1547-52; discussion 1553 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Aalborg Hospital, Aalborg, Denmark. laurberg@aas.nja.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fetal Blood / chemistry Humans Infant Infant, Newborn Iodine / blood, deficiency*, metabolism*, urine Male Nutrition Assessment* Nutritional Status* Pregnancy Pregnancy Complications / blood, epidemiology Sensitivity and Specificity Thyroid Gland / physiology* Thyrotropin / blood Thyroxine / blood Triiodothyronine / blood |
| Chemical | |
Reg. No./Substance:
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6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 7553-56-2/Iodine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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