Document Detail

Evaluating intermediate coronary lesions in the cardiac catheterization laboratory.
MedLine Citation:
PMID:  12684598     Owner:  NLM     Status:  MEDLINE    
Angiography is notoriously poor at distinguishing ischemia-producing from non-ischemia-producing intermediate coronary lesions. Here, three invasive modalities for evaluating the physiologic significance of moderate coronary stenoses are reviewed: Doppler wire-derived measurement of coronary flow reserve (CFR), coronary pressure wire-derived fractional flow reserve (FFR), and intravascular ultrasound (IVUS) imaging. Studies investigating the correlation between each of these modalities and various noninvasive tests (eg, nuclear perfusion imaging or stress echocardiography) are discussed. Each of these invasive modalities has its limitations: CFR is limited by its dependence on heart rate and blood pressure, calling into question its reproducibility; both FFR and CFR are limited by their reliance upon achieving maximal hyperemia; and IVUS is limited by the fact that it provides anatomic information only. Ultimately, FFR appears to be the ideal method for interrogating intermediate coronary lesions.
William F Fearon; Alan C Yeung
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews in cardiovascular medicine     Volume:  4     ISSN:  1530-6550     ISO Abbreviation:  Rev Cardiovasc Med     Publication Date:  2003  
Date Detail:
Created Date:  2003-04-09     Completed Date:  2003-05-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100960007     Medline TA:  Rev Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
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MeSH Terms
Coronary Stenosis / diagnosis*,  physiopathology,  ultrasonography
Coronary Vessels / physiopathology,  ultrasonography
Heart Catheterization
Regional Blood Flow
Ultrasonography, Interventional

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