Document Detail


Evaluating atypical dementia syndromes using positron emission tomography with carbon 11 labeled Pittsburgh Compound B.
MedLine Citation:
PMID:  17698704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: A progressive decline in episodic memory affecting activities of daily living is the usual clinical presentation of Alzheimer disease. However, patients presenting with atypical or focal clinical symptoms such as language or visuospatial dysfunction often pose a diagnostic challenge. OBJECTIVE: To explore the presence and topography of beta amyloid (Abeta) as measured by carbon 11-labeled Pittsburgh Compound B ((11)C-PiB) in patients with atypical presentations of dementia. DESIGN, SETTING, AND PARTICIPANTS: At a tertiary referral center for memory disorders, 15 healthy controls, 10 patients with Alzheimer disease, a patient with primary progressive aphasia (PPA), and a patient with posterior cortical atrophy (PCA) underwent (11)C-PiB positron emission tomographic studies. Retention of (11)C-PiB was compared between different groups using statistical parametric mapping. MAIN OUTCOME MEASURE: The topography of cortical (11)C-PiB binding in atypical vs typical Alzheimer disease. RESULTS: Cortical (11)C-PiB binding was higher in the group with Alzheimer disease and in the patients with PPA and PCA than the controls (P < .001). Both patients with atypical dementia had a similar (11)C-PiB binding pattern to Alzheimer disease although (11)C-PiB retention was higher on the left cerebral hemisphere in the patient with PPA (P < .01) and higher in the occipital cortex in the patient with PCA (P < .01). CONCLUSIONS: The presence of distinctive focal (11)C-PiB retention patterns was demonstrated in 2 patients with atypical onset of dementia. Pittsburgh Compound B has the potential to facilitate differential diagnosis of dementia and identify patients who could benefit from specific therapeutic strategies aimed at beta amyloid reduction.
Authors:
Steven Y Ng; Victor L Villemagne; Colin L Masters; Christopher C Rowe
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  64     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-09-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1140-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Nuclear Medicine and Centre for Positron Emission Tomography, Austin Health, Melbourne, Australia.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / metabolism,  radionuclide imaging
Amyloid beta-Protein / metabolism*
Aniline Compounds / diagnostic use*
Aphasia, Primary Progressive / metabolism*,  radionuclide imaging
Atrophy
Brain / radionuclide imaging
Carbon Radioisotopes / diagnostic use*
Dementia / diagnosis,  metabolism*,  radionuclide imaging
Female
Humans
Male
Middle Aged
Parietal Lobe / pathology*
Positron-Emission Tomography*
Syndrome
Thiazoles / diagnostic use*
Tissue Distribution
Chemical
Reg. No./Substance:
0/2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; 0/Amyloid beta-Protein; 0/Aniline Compounds; 0/Carbon Radioisotopes; 0/Thiazoles

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