| Evaluating the ability to detect change of health-related quality of life in children with Hodgkin disease. | |
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MedLine Citation:
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PMID: 20143448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We evaluated 4 different health-related quality of life (HRQL) measures prospectively to determine their ability to detect change over time: the Health Utilities Index Mark 2 and Mark 3, the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core and Cancer Module, the EuroQol EQ-5D visual analogue scale (EuroQol), and the Lansky Play-Performance Scale. METHODS: Children with all stages of Hodgkin disease from 12 centers across Canada were asked to complete the 4 measures at 4 time points: 2 weeks after the first course of chemotherapy, on the third day of the second course of chemotherapy, during the third week of radiation, and 1 year after diagnosis. RESULTS: Fifty-one patients were enrolled in the study between May 1, 2002 and March 31, 2005. Two patients were excluded: 1 patient died shortly after the first time point and the other patient failed to complete any of the questionnaires. All measures showed a significant change between Time 1 and Time 4 (<0.05). When the change in child scores was analyzed between the time points using the child's self-reported change in HRQL, the PedsQL and the EuroQol showed significant change at all time points. CONCLUSIONS: All of the measures were able to detect change in a diverse group of children with Hodgkin disease. The PedsQL and the EuroQol appeared to be the most sensitive to change. |
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Authors:
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Robert J Klaassen; Murray Krahn; Isabelle Gaboury; Joanna Hughes; Ronald Anderson; Paul Grundy; S Kaiser Ali; Lawrence Jardine; Oussama Abla; Mariana Silva; Dorothy Barnard; Mario Cappelli |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer Volume: 116 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1608-14 Citation Subset: AIM; IM |
Affiliation:
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Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital of Eastern Ontario, 401 Smyth, Ottawa, Ontario, Canada K1H 8L1. rklaassen@cheo.on.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Female Health Status* Hodgkin Disease / psychology* Humans Male Psychometrics / methods* Quality of Life* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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