| Evaluating the Toxicity of Hydroxyapatite Nanoparticles in Catfish Cells and Zebrafish Embryos. | |
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MedLine Citation:
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PMID: 22887936 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The toxicity of needle-(nHA-ND) and rod-shaped (nHA-RD) hydroxyapatite (HA) nanoparticles is evaluated in vitro on catfish B-cells (3B11) and catfish T-cells (28s.3) and in vivo on zebrafish embryos to determine if biological effects are similar to the effects seen in mammalian in vitro systems. Neither nHA-ND nor nHA-RD affect cell viability at concentrations of 10 to 300 μg mL(-1) . However, 30 μg mL(-1) needle-shaped nHA lower metabolic activity of the cells. Axial deformations are seen in zebrafish exposed to 300 μg mL(-1) needle shaped nHA after 120 h. For the first time, nHA is reported to cause zebrafish hatching delay. The lowest concentration (3 μg mL(-1) ) of both types of nHA cause the highest hatching inhibition and needle-shaped nHA exposed zebrafish exhibit the lowest hatch at 72 h post fertilization. |
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Authors:
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Xinxin Zhao; Kimberly J Ong; James D Ede; James L Stafford; Kee Woei Ng; Greg G Goss; Say Chye Joachim Loo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-9 |
Journal Detail:
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Title: Small (Weinheim an der Bergstrasse, Germany) Volume: - ISSN: 1613-6829 ISO Abbreviation: Small Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101235338 Medline TA: Small Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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