Document Detail

Evaluating a simple method of neuroprotective hypothermia for newborn infants.
MedLine Citation:
PMID:  19793894     Owner:  NLM     Status:  MEDLINE    
This study describes and evaluates a simple method of neuroprotective hypothermia for infants with hypoxic-ischaemic encephalopathy (HIE). Five term infants with HIE were cooled by applying soft, cold gel bags to the head. A radiant warmer, set to 34 degrees C, servo-controlled the temperature measured at a probe between the infant's back and the mattress. The infants' heads were shielded from the warmer. After 72 h, the infants were re-warmed by 0.2 degrees C per hour, by adjusting the radiant warmer. A rectal temperature of 34 degrees C was attained in a median time of 45 min. Mean rectal temperatures during cooling were 33.9 +/- 0.3 degrees C. There was good correlation between insulated back temperatures and deep rectal temperatures (r = 0.76). There were no major or irreversible adverse events during cooling. This method of cooling achieved rectal temperatures within the target range of 33-34 degrees C and re-warming was effective.
A R Horn; M C Harrison; L L Linley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-30
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  56     ISSN:  1465-3664     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-27     Completed Date:  2010-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  172-7     Citation Subset:  IM    
Neonatal Medicine, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
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MeSH Terms
Body Temperature
Gestational Age
Hypothermia, Induced / instrumentation*,  methods
Hypoxia-Ischemia, Brain / etiology,  therapy*
Infant, Newborn
Prospective Studies
Time Factors
Treatment Outcome

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