| Evaluating a simple method of neuroprotective hypothermia for newborn infants. | |
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MedLine Citation:
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PMID: 19793894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study describes and evaluates a simple method of neuroprotective hypothermia for infants with hypoxic-ischaemic encephalopathy (HIE). Five term infants with HIE were cooled by applying soft, cold gel bags to the head. A radiant warmer, set to 34 degrees C, servo-controlled the temperature measured at a probe between the infant's back and the mattress. The infants' heads were shielded from the warmer. After 72 h, the infants were re-warmed by 0.2 degrees C per hour, by adjusting the radiant warmer. A rectal temperature of 34 degrees C was attained in a median time of 45 min. Mean rectal temperatures during cooling were 33.9 +/- 0.3 degrees C. There was good correlation between insulated back temperatures and deep rectal temperatures (r = 0.76). There were no major or irreversible adverse events during cooling. This method of cooling achieved rectal temperatures within the target range of 33-34 degrees C and re-warming was effective. |
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Authors:
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A R Horn; M C Harrison; L L Linley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-30 |
Journal Detail:
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Title: Journal of tropical pediatrics Volume: 56 ISSN: 1465-3664 ISO Abbreviation: J. Trop. Pediatr. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010948 Medline TA: J Trop Pediatr Country: England |
Other Details:
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Languages: eng Pagination: 172-7 Citation Subset: IM |
Affiliation:
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Neonatal Medicine, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. alan.horn@uct.ac.za |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Body Temperature Gestational Age Humans Hypothermia, Induced / instrumentation*, methods Hypoxia-Ischemia, Brain / etiology, therapy* Infant, Newborn Prospective Studies Time Factors Treatment Outcome |
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