| Evaluating the InterVA model for determining AIDS mortality from verbal autopsies in the adult population of Addis Ababa. | |
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MedLine Citation:
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PMID: 20214760 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the performance of a verbal autopsy (VA) expert algorithm (the InterVA model) for diagnosing AIDS mortality against a reference standard from hospital records that include HIV serostatus information in Addis Ababa, Ethiopia. METHODS: Verbal autopsies were conducted for 193 individuals who visited a hospital under surveillance during terminal illness. Decedent admission diagnosis and HIV serostatus information are used to construct two reference standards (AIDS vs. other causes of death and TB/AIDS vs. other causes). The InterVA model is used to interpret the VA interviews; and the sensitivity, specificity and cause-specific mortality fractions are calculated as indicators of the diagnostic accuracy of the InterVA model. RESULTS: The sensitivity and specificity of the InterVA model for diagnosing AIDS are 0.82 (95% CI: 0.74-0.89) and 0.76 (95% CI: 0.64-0.86), respectively. The sensitivity and specificity for TB/AIDS are 0.91 (95% CI: 0.85-0.96) and 0.78 (95% CI: 0.63-0.89), respectively. The AIDS-specific mortality fraction estimated by the model is 61.7% (95% CI: 54-69%), which is close to 64.7% (95% CI: 57-72%) in the reference standard. The TB/AIDS mortality fraction estimated by the model is 73.6% (95% CI: 67-80%), compared to 74.1% (95% CI: 68-81%) in the reference standard. CONCLUSION: The InterVA model is an easy to use and cheap alternative to physician review for assessing AIDS mortality in populations without vital registration and medical certification of causes of death. The model seems to perform better when TB and AIDS are combined, but the sample is too small to statistically confirm that. |
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Authors:
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Biruk Tensou; Tekebash Araya; Daniel S Telake; Peter Byass; Yemane Berhane; Tolcha Kebebew; Eduard J Sanders; Georges Reniers |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2010-03-01 |
Journal Detail:
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Title: Tropical medicine & international health : TM & IH Volume: 15 ISSN: 1365-3156 ISO Abbreviation: Trop. Med. Int. Health Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-05-20 Revised Date: 2011-10-03 |
Medline Journal Info:
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Nlm Unique ID: 9610576 Medline TA: Trop Med Int Health Country: England |
Other Details:
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Languages: eng Pagination: 547-53 Citation Subset: IM |
Affiliation:
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Addis Ababa Mortality Surveillance Project, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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mortality* Adolescent Adult Aged Aged, 80 and over Algorithms* Autopsy / methods* Cause of Death Data Collection Developing Countries / statistics & numerical data Ethiopia / epidemiology HIV Infections / mortality Humans Male Middle Aged Population Surveillance / methods Questionnaires Reference Standards Sensitivity and Specificity Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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5U22 PS 022179-05/PS/NCHHSTP CDC HHS; R24 HD047879-05/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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