Document Detail

Evaluating bleeding severity in children with newly diagnosed immune thrombocytopenia: a pilot study.
MedLine Citation:
PMID:  21058224     Owner:  NLM     Status:  In-Process    
BACKGROUND: Childhood immune thrombocytopenia (ITP) is a bleeding disorder characterized by decreased platelet counts. Assessment of the individual bleeding risk during the course of the disease would allow more accurately guiding treatment-related decisions in these patients.
PATIENTS AND METHODS: We conducted a pilot study and prospectively evaluated platelet counts and bleeding signs using an established bleeding (Buchanan) score in 30 patients with newly diagnosed ITP at 3 different time points (at diagnosis [TP1], on day 2-3 [TP2], and on day 5-8 [TP3]) during the first week after diagnosis. 15 patients received immune modulatory therapy.
RESULTS: Median platelet counts at the 3 different time points were 13, 19, 32×10 (9)/L (untreated patients) and 2, 7, 37×10 (9)/L (treated patients). Corresponding median cumulative bleeding scores were 5, 2, 0 (untreated patients) and 7, 6, 2 (treated patients). Cumulative median bleeding scores and platelet counts were inversely correlated in treated and untreated patients at all 3 time points. Cumulative median bleeding scores significantly decreased in both groups.
CONCLUSIONS: Bleeding signs in children with newly diagnosed ITP rapidly improve within one week after diagnosis. Serial grading of bleeding severity seems to be useful to comprehensively assess and monitor the individual bleeding risk in these patients, but has to be evaluated and validated in a larger cohort.
J Pansy; M Minkov; R Dengg; F Quehenberger; H Lackner; A Nebl; P Sovinz; W Schwinger; C Urban; M Benesch
Related Documents :
19789834 - Combined tips with portal-azygous disconnection improved the long term clinical outcome...
10556404 - Massive lower gastrointestinal hemorrhage from the surgical anastomosis in patients wit...
12117894 - Idiopathic non-cirrhotic intrahepatic portal hypertension in the west: a re-evaluation ...
11837564 - Warfarin-associated bleeding complication saved life.
8090334 - Treatment of fungal peritonitis complicating continuous ambulatory peritoneal dialysis ...
23445314 - Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hyd...
Publication Detail:
Type:  Journal Article     Date:  2010-11-05
Journal Detail:
Title:  Klinische Pädiatrie     Volume:  222     ISSN:  1439-3824     ISO Abbreviation:  Klin Padiatr     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326144     Medline TA:  Klin Padiatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  374-7     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 30, Graz, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Therapeutic implications of the IL-21: IL-4 receptor system in children with common variable immunod...
Next Document:  Paraneoplastic myopathy as a very rare manifestation of acute lymphoblastic leukemia.