| Eutopic or ectopic pregnancy: a competition between signals derived from the endometrium and the fallopian tube for blastocyst implantation. | |
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MedLine Citation:
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PMID: 19700192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Embryo retention in the fallopian tube is thought to lead to ectopic pregnancy, which is a significant cause of morbidity. This pathological condition does not occur in laboratory rodents. Moreover, incidences of tubal pregnancy after assisted reproduction (ART) are continuously increasing. What are the factors that need to be considered responsible for this condition? Ectopic pregnancies occur because of conflicting signals to the blastocyst from the two epithelia (uterine and fallopian). The signals consist of cytokines, chemokines and adhesion molecules that mediate both blastocyst adhesion to the uterine (and fallopian) epithelium and leukocyte adhesion to the vascular endothelium and, presumably, the fallopian epithelium. Chronic inflammation in the fallopian tube caused by infections or misplacements of the blastocyst (in the case of ART) can alter expression (upregulate) of the signals emanating from the fallopian tube and thereby can compete with the uterine (normal) site of implantation. That is, in ectopic pregnancy, a blastocyst may receive stronger signals from the tubal epithelia, migrate to the fallopian tube, and be implanted at that site. |
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Authors:
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Z Jia-Rong; L Shuang-Di; W Xiao-Ping |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-22 |
Journal Detail:
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Title: Placenta Volume: 30 ISSN: 1532-3102 ISO Abbreviation: Placenta Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-21 Completed Date: 2010-02-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: 835-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion Molecules / metabolism Chemotaxis, Leukocyte Embryo Implantation / physiology* Endometrium / metabolism* Fallopian Tubes / metabolism* Female Humans Models, Biological Paracrine Communication / physiology* Pregnancy Pregnancy, Ectopic / metabolism, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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