| Euthyroid and primarily hypothyroid patients develop milder and significantly more asymmetrical Graves ophthalmopathy. | |
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MedLine Citation:
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PMID: 19221109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Retrospective, observational study to compare clinical symptoms and TSH-receptor antibodies (TRAb) in Graves ophthalmopathy (GO) in euthyroid and primarily hypothyroid patients to those in hyperthyroid patients. METHODS: Clinical symptoms (NOSPECS (severity) and CAS (activity) score), prevalence and levels of thyroid specific antibodies and the course of the disease were evaluated in 143 primarily hyperthyroid, 28 primarily euthyroid and 11 primarily hypothyroid patients with GO. RESULTS: Patients with euthyroid/hypothyroid GO developed significantly less severe GO symptoms (NOSPECS score 4.4 vs 5.7; p = 0.03), less active GO (CAS score 3.9 vs 5.2; p = 0.002) and more asymmetrical disease (proptosis side difference: 1.9 mm vs 1.0 mm (p = 0.01); side difference of > or = 3 mm: 23% vs 4.8%) than hyperthyroid patients. TRAb levels 6 months after GO onset were significantly lower (2.2 IU/l, p = 0.02) in euthyroid/hypothyroid than in hyperthyroid patients (8.6 IU/l), as was the prevalence of both TRAb and thyroid peroxidase antibodies (75% vs 94.6%, p = 0.0008). CONCLUSIONS: The knowledge about the phenotype of GO in primarily euthyroid and hypothyroid patients is helpful for differential diagnosis and patient consultation. TRAb titres are very low in these patients, and the availability of a sensitive assay technique is therefore an important diagnostic tool in euthyroid and hypothyroid patients. |
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Authors:
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A K Eckstein; C Lösch; D Glowacka; M Schott; K Mann; J Esser; N G Morgenthaler |
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Publication Detail:
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Type: Journal Article Date: 2009-02-15 |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 93 ISSN: 1468-2079 ISO Abbreviation: Br J Ophthalmol Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-27 Completed Date: 2009-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 1052-6 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Essen, Essen, Germany. anja.eckstein@uk-essen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Autoantibodies / blood Female Graves Ophthalmopathy / complications*, immunology, pathology Humans Hypothyroidism / complications*, immunology, pathology Magnetic Resonance Imaging Male Middle Aged Receptors, Thyrotropin / immunology Retrospective Studies Severity of Illness Index Thyroid Gland / immunology, pathology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Receptors, Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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